AmiGO 2: Term Details for "inward rectifier potassium channel activity" (GO:0005242)

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Term Information

Accession: GO:0005242
Name: inward rectifier potassium channel activity
Ontology: molecular_function
Synonyms: Kir channel activity
Alternate IDs: None
Definition: Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. Source: GOC:cb, PMID:14977398, GOC:mah
Comment: None
History: See term history for GO:0005242 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to inward rectifier potassium channel activity (excluding "regulates").; Link to all direct and indirect annotations to inward rectifier potassium channel activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for inward rectifier potassium channel activity (excluding "regulates").

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GO:0008150 biological_process
GO:0051179 localization
GO:0051234 establishment of localization
GO:0009987 cellular process
GO:0003674 molecular_function
GO:0055085 transmembrane transport
GO:0022857 transmembrane transporter activity
GO:0006810 transport
GO:0098660 inorganic ion transmembrane transport
GO:0015318 inorganic molecular entity transmembrane transporter activity
GO:0030001 metal ion transport
GO:0006812 monoatomic cation transport
GO:0006811 monoatomic ion transport
GO:0005215 transporter activity
GO:0015267 channel activity
GO:0022836 gated channel activity
GO:0098662 inorganic cation transmembrane transport
GO:0022890 inorganic cation transmembrane transporter activity
GO:0098655 monoatomic cation transmembrane transport
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0034220 monoatomic ion transmembrane transport
GO:0022803 passive transmembrane transporter activity
GO:0006813 potassium ion transport
GO:0046873 metal ion transmembrane transporter activity
GO:0005216 monoatomic ion channel activity
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0071805 potassium ion transmembrane transport
GO:0022832 voltage-gated channel activity
GO:0022834 ligand-gated channel activity
GO:0005261 monoatomic cation channel activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0005267 potassium channel activity
GO:0022843 voltage-gated monoatomic cation channel activity
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005242 inward rectifier potassium channel activity
GO:0015272 ATP-activated inward rectifier potassium channel activity
GO:0015467 G-protein activated inward rectifier potassium channel activity
GO:1902937 inward rectifier potassium channel complex
GO:1903609 negative regulation of inward rectifier potassium channel activity
GO:1901980 positive regulation of inward rectifier potassium channel activity
GO:1901979 regulation of inward rectifier potassium channel activity

Parents of inward rectifier potassium channel activity (GO:0005242)

subject	relation	object
inward rectifier potassium channel activity	is_a	ligand-gated monoatomic cation channel activity (GO:0099094)
inward rectifier potassium channel activity	is_a	voltage-gated potassium channel activity (GO:0005249)

Children of inward rectifier potassium channel activity (GO:0005242)

subject	relation	object
inward rectifier potassium channel inhibitor activity (GO:0070320)	RO:0002630	inward rectifier potassium channel activity
positive regulation of inward rectifier potassium channel activity (GO:1901980)	RO:0002213	inward rectifier potassium channel activity
ATP-activated inward rectifier potassium channel activity (GO:0015272)	is_a	inward rectifier potassium channel activity
regulation of inward rectifier potassium channel activity (GO:1901979)	RO:0002211	inward rectifier potassium channel activity
G-protein activated inward rectifier potassium channel activity (GO:0015467)	is_a	inward rectifier potassium channel activity
negative regulation of inward rectifier potassium channel activity (GO:1903609)	RO:0002212	inward rectifier potassium channel activity
inward rectifier potassium channel complex (GO:1902937)	RO:0002215	inward rectifier potassium channel activity

Reactome: R-HSA-9731072; R-HSA-1369017; R-HSA-1296045; R-HSA-1296046; R-HSA-5678418; R-HSA-9730521; R-HSA-5678261; R-HSA-9729870