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Ammonium formate

Ammonium formate Structure
Ammonium formate structure
CAS No.
540-69-2
Chemical Name:
Ammonium formate
Synonyms
AMMONIUM FORMAT;AMMONIUM FORMIATE;Ammomium formate;HCOONH4 CH5NO2;mravencanamonny;97.0%， for HPLC;Formiate ammonia;AMMONIUM FORMATE;ammmonium formate;formated’ammonium
CBNumber:
CB3140017
Molecular Formula:
CH5NO2
Molecular Weight:
63.06
MDL Number:
MFCD00013103
MOL File:
540-69-2.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02
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Ammonium formate Properties

Melting point 119-121 °C (lit.)
Boiling point 103.28°C (rough estimate)
Density 1.26 g/mL at 25 °C (lit.)
vapor pressure 0.033Pa at 25℃
refractive index 1.4164 (estimate)
Flash point 104℃
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 10 M at 20 °C, clear, colorless
form Solid
color White
PH 6.53(1 mM solution);6.5(10 mM solution);6.49(100 mM solution);6.45(1000 mM solution)
Odor Slight formic acid odour
PH Range 6 - 7
Water Solubility soluble
Sensitive Hygroscopic
λmax λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.04
Merck 14,523
BRN 3625095
Stability Stable. Hygroscopic. Incompatible with strong acids, strong oxidizing agents.
InChIKey VZTDIZULWFCMLS-UHFFFAOYSA-N
LogP -3.34 at 25℃
FDA 21 CFR 573.170
CAS DataBase Reference 540-69-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 3801F9644E
EPA Substance Registry System Ammonium formate (540-69-2)
UNSPSC Code 12352300
NACRES NB.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  2
RTECS  BQ6650000
F  3-10
TSCA  Yes
HS Code  29151200
Hazardous Substances Data 540-69-2(Hazardous Substances Data)
Toxicity LD50 orl-mus: 2250 mg/kg ZERNAL 9,332,69
NFPA 704
1
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Ammonium formate price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 78314 Ammonium formate solution BioUltra, 10?M in H2O 540-69-2 100mL $107 2024-03-01 Buy
Sigma-Aldrich 78314 Ammonium formate solution BioUltra, 10?M in H2O 540-69-2 500mL $373 2024-03-01 Buy
Sigma-Aldrich 70221 Ammonium formate eluent additive for LC-MS, LiChropur?, ≥99.0% 540-69-2 25g $170 2024-03-01 Buy
Sigma-Aldrich 70221 Ammonium formate eluent additive for LC-MS, LiChropur?, ≥99.0% 540-69-2 100g $617 2024-03-01 Buy
Sigma-Aldrich 156264 Ammonium formate reagent grade, 97% 540-69-2 1kg $144 2024-03-01 Buy
Product number Packaging Price Buy
78314 100mL $107 Buy
78314 500mL $373 Buy
70221 25g $170 Buy
70221 100g $617 Buy
156264 1kg $144 Buy

Ammonium formate Chemical Properties,Uses,Production

Chemical Properties

Ammonium formate, NH4HCO2, is the ammonium salt of formic acid. It is a colorless, hygroscopic, crystalline solid. It can be synthesized through treating ammonium carbonate with 85% formic acid. It is widely used in many organic reactions such as Leuckart reaction which is the reductive amination of aldehydes and ketones. It can also be used as a buffer in HPLC and LC/MS test. Moreover, it is also used in palladium on carbon (Pd/C) reduction of functional group. It can also be used for the preparation of formic acid in situ as well as being used to store formic acid.
Common HPLC Buffers: Ammonium formate (2.7<PH<3.7)
Common HPLC Buffers: Ammonium formate (2.7<PH<3.7) does a fairly good job of filling the gap at the low-pH end.

Physical properties

White monoclinic deliquescent crystals or granules; density 1.280 g/cm3; melts at 116°C; highly soluble in water (102 g/100 g at 0°C), solubility rapidly increasing with temperature (i.e., 531 g/100 g at 80°C); soluble in liquid ammonia, alcohol and ether.

Uses

Ammonium formate is widely used in various organic reactions like Leuckart reaction which involves the reductive amination of aldehydes and ketones. It serves as a buffer in high performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC/MS). It finds application in palladium on carbon (Pd/C) reduction of functional groups. For example, reduction of alkenes to alkanes and formaldehyde to methanol. It is also used to prepare formic acid insitu as well as used to store formic acid by making it as an ammonium salt.

Uses

Pure ammonium formate decomposes into formamide and water when heated, and this is its primary use in industry. Formic acid can also be obtained by reacting ammonium formate with a dilute acid, and since ammonium formate is also produced from formic acid, it can serve as a way of storing formic acid.
In chemical analysis, especially to ppt base metals from salts of the "noble" metals. Ammonium formate can also be used in palladium on carbon (Pd / C) reduction of functional groups. In the presence of Pd / C, ammonium formate decomposes to hydrogen, carbon dioxide, and ammonia.
Ammonium formate can be used for reductive amination of aldehydes and ketones (Leuckart reaction)
Ammonium formate can be used as a buffer in high performance liquid chromatography (HPLC), and is suitable for use with liquid chromatography/mass spectrometry (LC/MS). .

Definition

ChEBI: Ammonium formate is the ammonium salt of formic acid. It has a role as a buffer. It is functionally related to a formic acid.

Reactions

When heated, ammonium formate eliminates water, forming formamide. Upon further heating it forms to HCN and H2O. A side reaction of this is the decomposition of formamide to CO and NH3.

Air & Water Reactions

Ammonium formate is generally soluble in water. 

Reactivity Profile

Salts, basic, such as Ammonium formate, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Health Hazard

Inhalation causes irritation of nose and throat. Ingestion irritates mouth and stomach. Contact with eyes or skin causes irritation.

Fire Hazard

Special Hazards of Combustion Products: Toxic and irritating ammonia and formic acid gases may form in fire.

Safety Profile

Moderately toxic by ingestion andintravenous routes. When heated to decomposition itemits toxic fumes of NOx and NH3.

Purification Methods

Heat the solid in NH3 vapour and dry it in a vacuum till the NH3 odour is faint (note that it can evaporate completely in a vacuum). Recrystallise it from absolute EtOH and then keep it in a desiccator over 99% H2SO4 in vacuo. It is very hygroscopic. It exists in two forms, stable needles and less stable plates. It also forms acid salts, i.e. HCO2NH4.3HCO2H and HCO2NH4.HCO2H. [Kensall & Adler J Am Chem Soc 43 1473 1921, Beilstein 2 IV 18.]

References

[1] http://www.orgsyn.org/demo.aspx?prep=CV2P0503
[2] https://www.alfa.com/zh-cn/catalog/014517/
[3] https://en.wikipedia.org/wiki/Ammonium_formate
[4] GAO X, MA Y, ZHOU F, et al. Promotion Mechanism of Ammonium Formate in Ammonium Salt Leaching Process for Weathered Crust Elution-Deposited Rare Earth Ores[J]. Minerals, 2023, 1 1: 0. DOI:10.3390/min13101286.
[5] A. S. KORNILOV. Uranium Stripping with Ammonium Acetate and Formate[J]. Radiochemistry, 2024, 65 1 supplement: S172-S176. DOI:10.1134/S1066362223070159.
[6] ISHANI BORTHAKUR, SABUJ KUNDU* Reductive Aminomethylation Using Ammonium Formate and Methanol as N1 and C1 Source: Direct Synthesis of Mono- and Di-Methylated Amines[J]. ACS Catalysis , 2024, 14 8: 5847-5857. DOI:10.1021/acscatal.4c00346.

Ammonium formate synthesis

5436-21-5
60100-09-6
3438-46-8
67-56-1
540-69-2
Synthesis of Ammonium formate from Acetylacetaldehyde dimethyl acetal and formamide

Ammonium formate Preparation Products And Raw materials

Raw materials

4-Chlorobenzaldehyde Formic acid Ammonia

Preparation Products

3-Azetidinecarboxylic acid 4-(Trifluoromethyl)nicotinic acid (R)-(-)-2-AMINOHEPTANE 5-Fluoro-2-picolinic acid (1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)METHYLAMINE
1-N-Boc-3-hydroxyazetidine C-(1-METHYL-PIPERIDIN-2-YL)-METHYLAMINE 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID 1,2,4-Triazole Citrazinic acid
4-METHYLOXAZOLE-5-CARBONYL CHLORIDE 3,4,5-Trimethoxybenzylamine 5-(AMINOMETHYL)-2,3-DIHYDROBENZO[B]FURAN 4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE Teicoplanin A2
3-Chlorobenzylamine DL-alpha-Methylbenzylamine 4-Aminotetrahydropyran 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID 4-CHLORO-2-METHYLBENZYLAMINE
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one (4S)-HYDROXY-3-METHYL-2-(2-PROPENYL)-2-CYCLOPENTENE-1-ONE 3-(4-Morpholinyl)aniline 5-amino-1H-Indole-2-carboxylic acid ethyl ester 5-Azaindole
(1H-INDAZOL-3-YL)-ACETIC ACID 4-Hydroxy-3-methoxybenzylamine hydrochloride 3-Amino-5-fluoropyridine DL-ALPHA-METHYLBENZYLAMINE Triadimefon
ETHYL 5-AMINO-1H-INDOLE-2-CARBOXYLATE 3,5-Bis(trifluoromethyl)benzylamine 3-Amino-4-methoxybenzoic acid 2,5-Dimethoxybenzylamine

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Ammonium formate Suppliers

Global( 539)Suppliers
Supplier Tel Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Jiangsu Kolod Food Ingredients Co.,Ltd.
+8618805133257 sales3257@jskolod.com China 132 60
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531157085 abby@chuanghaibio.com China 8808 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-15536356810 1022@dideu.com China 3882 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12814 58
Dorne Chemical Technology co. LTD 		+86-86-13583358881 +8618560316533 Ethan@dornechem.com China 3084 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5870 58
Hebei Kingfiner Technology Development Co.Ltd 		+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3005 58
Shandong Juchuang Chemical Co., LTD 		+16837774622 admin@juchuangchem.com China 295 58
airuikechemical co., ltd. 		+86-18353166132 +86-18353166132 sales02@airuikechemical.com China 983 58
Supplier Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
58
Jiangsu Kolod Food Ingredients Co.,Ltd.
60
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Dorne Chemical Technology co. LTD 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Kingfiner Technology Development Co.Ltd 		58
Shandong Juchuang Chemical Co., LTD 		58
airuikechemical co., ltd. 		58

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View Lastest Price from Ammonium formate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ammonium formate pictures 2025-04-20 Ammonium formate
540-69-2
 US $1.00 / g 1g 99% 1000kg Dorne Chemical Technology co. LTD
Ammonium formate pictures 2025-04-18 Ammonium formate
540-69-2
 US $10.00-8.00 / kg 1kg 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
Ammonium formate pictures 2025-04-16 Ammonium formate
540-69-2
 US $0.00 / Kg/Bag 25KG 98%min 20 TONS WUHAN FORTUNA CHEMICAL CO., LTD
  • Ammonium formate pictures
  • Ammonium formate
    540-69-2
  • US $10.00-8.00 / kg
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

Ammonium formate Spectrum

Ammonium formate(540-69-2)1HNMRAmmonium formate(540-69-2)13CNMRAmmonium formate(540-69-2)IR1Ammonium formate(540-69-2)IR2Ammonium formate(540-69-2)Raman

540-69-2(Ammonium formate)Related Search:

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