24678-65-7Relevant articles and documents
Synthesis, spectral characterization, crystal structures and catalytic activity of a series of lanthanide(III) azepane dithiocarbamate complexes
Pitchaimani, Ponnuchamy,Lo, Kong Mun,Elango, Kuppanagounder P.
, p. 60 - 66 (2013)
A series of lanthanide(III) azepane dithiocarbamate (Aze-Dtc) complexes, [Ln(Aze-Dtc)3(Phen)] where Ln = La(III), Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Tb(III), Dy(III) and Er(III), have been synthesized under mild reaction conditions wi
Synthesis and characterization of the first Te(IV) organometallic complexes with azepane-1-carbodithioate
Cotero-Villegas, Ave María,Moya-Cabrera, Mónica,Jancik, Vojtech,Pérez-Redondo, María del Carmen,Martínez-Salas, Patricia,Cea-Olivares, Raymundo
, p. 338 - 343 (2017)
We report the synthesis and spectroscopic characterization of organometallic Te(IV) complexes bearing the seven-membered azepane-1-carbodithioate ligand and four different types of tellurium(IV) heterocycles; [C4H8Te{S2C-N(CH2)6}2](2),[C8H8Te{S2C-N(CH2)6}2](3),[C4H8OTe{S2C-N(CH2)6}2](4)and [C5H10Te{S2C-N(CH2)6}2](5). Compounds 2–5, obtained in a 2:1 stoichiometric ratio, are air-stable for long periods of time, but readily decompose in solution. They have been characterized by elemental analyses, IR, FAB+–MS, and multinuclear NMR (1H,13C, and125Te) spectroscopy. The molecular structures of 2 and 5 were established by single-crystal X-ray diffraction studies. The geometrical arrangement around the tellurium atom can be described as a distorted trigonalbipyramid or sawhorse structure, typical for tellurium atom, where the lone pair is apparently stereochemically active, occupying an equatorial position. The coordination mode for the azepane-1-carbodithioate ligands is considered as anisobidentate. Due to the orthogonal arrangement of the dithiocarbamate groups around tellurium, it is difficult for other atoms to approach and in consequence there are not intermolecular secondary interactions.
Organotin(IV) azepane dithiocarbamates: Synthesis and characterization of the first organotin(IV) complexes with seven-membered cyclic dithiocarbamates
Cotero-Villegas, Ave María,Pérez-Redondo, María del Carmen,López-Cardoso, Marcela,Toscano, Alfredo,Cea-Olivares, Raymundo
, p. 498 - 506 (2020)
We report the synthesis and spectroscopic characterization of the first organotin(IV) complexes with cyclic seven-membered dithiocarbamate ligands: the azepane-1-carbodithioate and the homopiperazine-1,4-bis-carbodithioate with two different organotin ent
Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology
Mandalapu, Dhanaraju,Kushwaha, Bhavana,Gupta, Sonal,Krishna, Shagun,Srivastava, Nidhi,Shukla, Mahendra,Singh, Pratiksha,Chauhan, Bhavana S.,Goyani, Ravi,Maikhuri, Jagdamba P.,Sashidhara, Koneni V.,Kumar, Brijesh,Tripathi, Renu,Shukla, Praveen K.,Siddiqi, Mohammad I.,Lal, Jawahar,Gupta, Gopal,Sharma, Vishnu L.
, p. 632 - 645 (2017/12/08)
Sexually transmitted diseases like trichomoniasis along with opportunistic fungal infections like candidiasis are major global health burden in female reproductive health. In this context a novel non-nitroimidazole class of substituted carbamothioic amine-1-carbothioic thioanhydride series was designed, synthesized, evaluated for trichomonacidal and fungicidal activities, and was found to be more active than the standard drug Metronidazole (MTZ). Compounds were trichomonicidal in the MIC ranges of 4.77–294.1 μM and 32.46–735.20 μM against MTZ-susceptible and -resistant strains, respectively. Further, compounds inhibited the growth of at least two out of ten fungal strains tested at MIC of 7.50–240.38 μM. The most active compound (20) of this series was 3.8 and 9.5 fold more active than the MTZ against the two Trichomonas strains tested. Compound 20 also significantly inhibited the sulfhydryl groups present over Trichomonas vaginalis and was found to be more active than the MTZ in vivo. Further, a docking analysis carried out with cysteine proteases supported their thiol inhibiting ability and preliminary pharmacokinetic study has shown good distribution and systemic clearance.
Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology
Lal, Nand,Jangir, Santosh,Bala, Veenu,Mandalapu, Dhanaraju,Sarswat, Amit,Kumar, Lalit,Jain, Ashish,Kumar, Lokesh,Kushwaha, Bhavana,Pandey, Atindra K.,Krishna, Shagun,Rawat, Tara,Shukla, Praveen K.,Maikhuri, Jagdamba P.,Siddiqi, Mohammad I.,Gupta, Gopal,Sharma, Vishnu L.
, p. 275 - 290 (2016/04/26)
Trichomoniasis and candidiasis are amongst the most common morbidity-causing reproductive tract infections, generally treated by Metronidazole and Fluconazole respectively. Poor vaginal efficacy, drug-resistance and non-spermicidal nature limit their use as topical microbicidal contraceptives. Bis(dialkylaminethiocarbonyl)disulfides (4-38) were designed as dually active, non-surfactant molecules capable of eliminating Trichomonas vaginalis and Candida strains as well as irreversibly immobilizing 100% human sperm instantly, at doses non-cytotoxic to human cervical epithelial cells and vaginal microflora in vitro. Compounds 12, 16, 17 were fifty times more active than nonoxynol-9, OTC vaginal spermicide, and compounds 12 and 17 have shown remarkable in vivo activity in rabbit model. Most promising compound 17 has shown promise for further development as a double-edged vaginal microbicide due to their improved activity and safety along with notable in vivo trichomonicidal activity. Role of disulfide group was established by loss of spermicidal activity on chemical modifications (39-56). These disulfides might be targeting thiol groups present over cell membrane of human sperm and Trichomonas as shown by fluorescence labeling of free thiols.
