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Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

Nature volume 364, pages 501–506 (1993)Cite this article

Abstract

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Paul Hasty & Allan Bradley

  2. Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, 77030, USA

    Allan Bradley

  3. Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA

    Paul Hasty, Julia H. Morris, Diane G. Edmondson, Judith M. Venuti, Eric N. Olson & William H. Klein

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  1. Paul Hasty
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Hasty, P., Bradley, A., Morris, J. et al. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature 364, 501–506 (1993). https://doi.org/10.1038/364501a0

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