Entry - *603953 - POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 14; KCNJ14 - OMIM

 
 
* 603953

POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 14; KCNJ14


Alternative titles; symbols

KIR2.4


HGNC Approved Gene Symbol: KCNJ14

Cytogenetic location: 19q13.33   Genomic coordinates (GRCh38) : 19:48,455,574-48,466,980 (from NCBI)


TEXT

▼ Cloning and Expression

Members of the inwardly rectifying potassium (Kir) channel family are characterized by a channel structure with 2 transmembrane segments surrounding putative pore loop. The Kir2 subfamily contains channels characterized by their strong current rectification. By screening a rat brain library with a bovine PCR fragment based on a human Kir-like EST (GenBank W25800), Topert et al. (1998) isolated a cDNA encoding Kir2.4, a Kir2 subfamily member. In situ hybridization revealed that Kir2.4 is expressed predominantly in motoneurons of cranial nerve motor nuclei within the general somatic and special visceral motor cell column. The unique Kir2.4 expression pattern and in situ measurements of the functional characteristics of Kir2.4 in rat brainstem led the authors to conclude that these channels serve an important function in controlling the excitability of brainstem motoneurons. Northern blot analysis revealed that Kir2.4 is expressed specifically in human brain.


▼ REFERENCES

  1. Topert, C., Doring, F., Wischmeyer, E., Karschin, C., Brockhaus, J., Ballanyi, K., Derst, C., Karschin, A. Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. J. Neurosci. 18: 4096-4105, 1998. [PubMed: 9592090, related citations] [Full Text]


Creation Date:
Rebekah S. Rasooly : 6/29/1999
Edit History:
alopez : 12/02/2010
alopez : 7/9/1999
jlewis : 7/1/1999
jlewis : 6/29/1999

* 603953

POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 14; KCNJ14


Alternative titles; symbols

KIR2.4


HGNC Approved Gene Symbol: KCNJ14

Cytogenetic location: 19q13.33   Genomic coordinates (GRCh38) : 19:48,455,574-48,466,980 (from NCBI)


TEXT

Cloning and Expression

Members of the inwardly rectifying potassium (Kir) channel family are characterized by a channel structure with 2 transmembrane segments surrounding putative pore loop. The Kir2 subfamily contains channels characterized by their strong current rectification. By screening a rat brain library with a bovine PCR fragment based on a human Kir-like EST (GenBank W25800), Topert et al. (1998) isolated a cDNA encoding Kir2.4, a Kir2 subfamily member. In situ hybridization revealed that Kir2.4 is expressed predominantly in motoneurons of cranial nerve motor nuclei within the general somatic and special visceral motor cell column. The unique Kir2.4 expression pattern and in situ measurements of the functional characteristics of Kir2.4 in rat brainstem led the authors to conclude that these channels serve an important function in controlling the excitability of brainstem motoneurons. Northern blot analysis revealed that Kir2.4 is expressed specifically in human brain.


REFERENCES

  1. Topert, C., Doring, F., Wischmeyer, E., Karschin, C., Brockhaus, J., Ballanyi, K., Derst, C., Karschin, A. Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. J. Neurosci. 18: 4096-4105, 1998. [PubMed: 9592090] [Full Text: https://doi.org/10.1523/JNEUROSCI.18-11-04096.1998]


Creation Date:
Rebekah S. Rasooly : 6/29/1999

Edit History:
alopez : 12/02/2010
alopez : 7/9/1999
jlewis : 7/1/1999
jlewis : 6/29/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2025 Johns Hopkins University.
Printed: April 22, 2025