SG10201603721TA - Anti-CTLA-4 Antibodies - Google Patents
Anti-CTLA-4 AntibodiesInfo
- Publication number
- SG10201603721TA SG10201603721TA SG10201603721TA SG10201603721TA SG10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA
- Authority
- SG
- Singapore
- Prior art keywords
- ctla
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70521—CD28, CD152
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG10201603721TA SG10201603721TA (en) | 2016-05-10 | 2016-05-10 | Anti-CTLA-4 Antibodies |
US15/486,468 US9758583B2 (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 antibodies |
AU2017262448A AU2017262448A1 (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 antibodies |
CA3023787A CA3023787A1 (en) | 2016-05-10 | 2017-04-13 | Anti-ctla-4 antibodies |
JP2018559329A JP6650537B2 (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 antibody |
SG11201809857TA SG11201809857TA (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 Antibodies |
EP17718870.3A EP3455255B1 (en) | 2016-05-10 | 2017-04-13 | Anti-ctla-4 antibodies |
US16/099,652 US11267887B2 (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 antibodies |
CN201780029330.5A CN109563165B (en) | 2016-05-10 | 2017-04-13 | anti-CTLA-4 antibodies |
PCT/EP2017/058956 WO2017194265A1 (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 Antibodies |
TW106112375A TW201739763A (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 antibodies |
KR1020187035791A KR20190015715A (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 antibody |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG10201603721TA SG10201603721TA (en) | 2016-05-10 | 2016-05-10 | Anti-CTLA-4 Antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201603721TA true SG10201603721TA (en) | 2017-12-28 |
Family
ID=58609383
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201603721TA SG10201603721TA (en) | 2016-05-10 | 2016-05-10 | Anti-CTLA-4 Antibodies |
SG11201809857TA SG11201809857TA (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 Antibodies |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201809857TA SG11201809857TA (en) | 2016-05-10 | 2017-04-13 | Anti-CTLA-4 Antibodies |
Country Status (10)
Country | Link |
---|---|
US (2) | US9758583B2 (en) |
EP (1) | EP3455255B1 (en) |
JP (1) | JP6650537B2 (en) |
KR (1) | KR20190015715A (en) |
CN (1) | CN109563165B (en) |
AU (1) | AU2017262448A1 (en) |
CA (1) | CA3023787A1 (en) |
SG (2) | SG10201603721TA (en) |
TW (1) | TW201739763A (en) |
WO (1) | WO2017194265A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2785692B1 (en) | 2011-12-01 | 2017-09-27 | ChemoCentryx, Inc. | Substituted anilines as ccr(4) antagonists |
ES2905525T3 (en) | 2015-05-06 | 2022-04-11 | Snipr Tech Ltd | Alteration of microbial populations and modification of the microbiota |
WO2016196237A1 (en) | 2015-05-29 | 2016-12-08 | Agenus Inc. | Anti-ctla-4 antibodies and methods of use thereof |
US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
SG10201603721TA (en) * | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
MA50949B1 (en) | 2016-12-07 | 2023-12-29 | Memorial Sloan Kettering Cancer Center | ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF |
WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | Anti-cd137 molecules and use thereof |
SG11202001604UA (en) * | 2017-09-21 | 2020-04-29 | Eucure Beijing Biopharma Co Ltd | Anti-ctla4 antibodies and uses thereof |
TWI800552B (en) | 2017-11-10 | 2023-05-01 | 新加坡科技研究局 | Il2rbeta/common gamma chain antibodies |
WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
WO2019148444A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Anti-ctla4 antibodies and methods of making and using the same |
US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
JP2021524282A (en) * | 2018-05-17 | 2021-09-13 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Receptor inhibition by phosphatase mobilization |
BR112021002928A2 (en) | 2018-08-29 | 2021-05-11 | Chemocentryx, Inc. | combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immunological checkpoint inhibitors |
WO2020094834A1 (en) | 2018-11-09 | 2020-05-14 | Euchloe Bio Pte. Ltd. | Il2rbeta/common gamma chain antibodies |
WO2020094836A1 (en) | 2018-11-09 | 2020-05-14 | Euchloe Bio Pte. Ltd. | Il2rbeta/common gamma chain antibodies |
BR112021012037A2 (en) | 2018-12-21 | 2021-11-03 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
IL316757A (en) * | 2018-12-27 | 2025-01-01 | Gigagen Inc | Anti-ctla-4 binding proteins and methods of use thereof |
WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
CN110343180B (en) * | 2019-07-25 | 2021-03-30 | 北京免疫方舟医药科技有限公司 | anti-CTLA-4 antibodies and uses thereof |
WO2021122866A1 (en) | 2019-12-17 | 2021-06-24 | Ose Immunotherapeutics | Bifunctional molecules comprising an il-7 variant |
AU2021287376A1 (en) * | 2020-06-11 | 2022-12-15 | Nantbio, Inc. | Anti-CTLA4 monoclonal antibodies and chimeric antigen receptors |
KR20230033719A (en) * | 2020-07-02 | 2023-03-08 | 기가젠, 인코포레이티드 | Anti-CTLA-4 binding proteins and methods of use thereof |
WO2022112198A1 (en) | 2020-11-24 | 2022-06-02 | Worldwide Innovative Network | Method to select the optimal immune checkpoint therapies |
KR20220112208A (en) * | 2021-02-03 | 2022-08-10 | 주식회사 유틸렉스 | Anti-CTLA-4 antibody and uses thereof |
RU2757418C1 (en) * | 2021-03-04 | 2021-10-15 | федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный университет" | Tetradecapeptide antagonist of interaction ctla-4 with b7-1 |
IL307419A (en) | 2021-04-09 | 2023-12-01 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
US20240182572A1 (en) | 2021-04-09 | 2024-06-06 | Ose Immunotherapeutics | Scaffold for bifunctional molecules comprising pd-1 or cd28 and sirp binding domains |
GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
WO2024003360A1 (en) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarkers and uses thereof for the treatment of neuroblastoma |
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
WO2024200823A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof |
WO2024200826A1 (en) | 2023-03-30 | 2024-10-03 | Ose Immunotherapeutics | Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell inhibiting molecule and use thereof |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE311895T1 (en) | 1992-05-26 | 2005-12-15 | Immunex Corp | NEW CYTOKINE THAT BINDS CD30 |
PT1212422E (en) | 1999-08-24 | 2007-04-30 | Medarex Inc | Human ctla-4 antibodies and their uses |
ITRM20010408A1 (en) | 2001-07-10 | 2003-01-10 | Univ Napoli Federico Ii | CYTOTOXIC HUMAN MINI-ANTIBODY FOR CANCER CELLS THAT EXPRESS THE ERBB2 RECEPTOR. |
BR0306808A (en) | 2002-01-09 | 2005-08-30 | Medarex Inc | Human Monoclonal Antibodies against cd30 |
SI2511297T1 (en) | 2004-02-06 | 2015-07-31 | Morphosys Ag | Anti-CD38 human antibodies and uses therefor |
PL2287195T3 (en) | 2004-07-01 | 2019-10-31 | Novo Nordisk As | Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy |
EP3153525A1 (en) | 2005-03-23 | 2017-04-12 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
AU2006244885B2 (en) | 2005-05-09 | 2011-03-31 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
TWI461436B (en) | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | Human monoclonal antibody human cd134 (ox40) and methods of making and using same |
DK2511301T3 (en) | 2006-08-04 | 2018-03-12 | Medimmune Ltd | HUMAN ANTIBODIES AGAINST ERBB 2 |
EP2087114B1 (en) | 2006-11-13 | 2013-05-29 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Methods of treating cancer using sirna molecules directed against cd24 |
DK2716301T3 (en) | 2007-02-16 | 2017-07-31 | Merrimack Pharmaceuticals Inc | ANTIBODIES AGAINST ERBB3 AND APPLICATIONS THEREOF |
AR069747A1 (en) | 2007-11-30 | 2010-02-17 | Medarex Inc | ANTI-B7H4 MONOCLONAL ANTIBODY CONJUGATE - PHARMACO AND METHODS OF USE |
EP4331604B1 (en) | 2008-12-09 | 2025-03-05 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
EP3009455A1 (en) | 2009-09-16 | 2016-04-20 | Immunomedics Inc. | Class i anti-cea antibodies and uses thereof |
ME03447B (en) | 2010-03-04 | 2020-01-20 | Macrogenics Inc | ANTIBODIES REACTING WITH B7-H3, ASSOCIATED IMMUNOLOGICALLY ACTIVE FRAGMENTS AND ASSOCIATED USES |
CA2800488A1 (en) | 2010-05-26 | 2011-12-01 | Regents Of The University Of Minnesota | Single-chain variable fragment anti-cd133 antibodies and uses thereof |
EA031849B1 (en) | 2010-08-23 | 2019-03-29 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Anti-ox40 antibodies and methods of using the same |
SI2703486T1 (en) | 2011-04-25 | 2018-05-31 | Daiichi Sankyo Company, Limited | Anti-b7-h3 antibody |
GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
US8791244B2 (en) | 2011-09-30 | 2014-07-29 | Regeneron Pharmaceuticals, Inc. | Anti-ErbB3 antibodies and uses thereof |
ES2861435T3 (en) | 2011-11-03 | 2021-10-06 | Univ Pennsylvania | Specific compositions of isolated B7-H4 and methods of using them |
CN109793893B (en) | 2012-09-07 | 2023-05-26 | 达特茅斯大学理事会 | VISTA modulators for diagnosis and treatment of cancer |
EP2912063A1 (en) | 2012-10-23 | 2015-09-02 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-ctla-4 antibodies to treat cancer |
SG11201504764SA (en) | 2012-12-19 | 2015-07-30 | Amplimmune Inc | Anti-human b7-h4 antibodies and their uses |
US9573988B2 (en) | 2013-02-20 | 2017-02-21 | Novartis Ag | Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells |
WO2014160627A1 (en) | 2013-03-25 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd276 polypeptides, proteins, and chimeric antigen receptors |
SMT201900332T1 (en) | 2013-09-20 | 2019-07-11 | Bristol Myers Squibb Co | Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors |
DK3087098T3 (en) | 2013-12-24 | 2020-06-08 | Janssen Pharmaceutica Nv | Anti-Vista antibodies and fragments |
CN104974253A (en) * | 2014-04-01 | 2015-10-14 | 上海中信国健药业股份有限公司 | Anti-CTLA-4/PD-1 bispecific antibody as well as preparation method and application thereof |
SG10201603721TA (en) * | 2016-05-10 | 2017-12-28 | Agency Science Tech & Res | Anti-CTLA-4 Antibodies |
-
2016
- 2016-05-10 SG SG10201603721TA patent/SG10201603721TA/en unknown
-
2017
- 2017-04-13 SG SG11201809857TA patent/SG11201809857TA/en unknown
- 2017-04-13 TW TW106112375A patent/TW201739763A/en unknown
- 2017-04-13 AU AU2017262448A patent/AU2017262448A1/en not_active Abandoned
- 2017-04-13 US US15/486,468 patent/US9758583B2/en active Active
- 2017-04-13 CN CN201780029330.5A patent/CN109563165B/en active Active
- 2017-04-13 JP JP2018559329A patent/JP6650537B2/en active Active
- 2017-04-13 WO PCT/EP2017/058956 patent/WO2017194265A1/en active Search and Examination
- 2017-04-13 US US16/099,652 patent/US11267887B2/en active Active
- 2017-04-13 EP EP17718870.3A patent/EP3455255B1/en active Active
- 2017-04-13 CA CA3023787A patent/CA3023787A1/en not_active Abandoned
- 2017-04-13 KR KR1020187035791A patent/KR20190015715A/en not_active Ceased
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US11267887B2 (en) | 2022-03-08 |
TW201739763A (en) | 2017-11-16 |
US20170226211A1 (en) | 2017-08-10 |
WO2017194265A1 (en) | 2017-11-16 |
CN109563165A (en) | 2019-04-02 |
JP2019519208A (en) | 2019-07-11 |
CA3023787A1 (en) | 2017-11-16 |
CN109563165B (en) | 2020-09-25 |
AU2017262448A1 (en) | 2019-01-03 |
JP6650537B2 (en) | 2020-02-19 |
SG11201809857TA (en) | 2018-12-28 |
EP3455255A1 (en) | 2019-03-20 |
EP3455255B1 (en) | 2021-03-03 |
US9758583B2 (en) | 2017-09-12 |
US20190153097A1 (en) | 2019-05-23 |
KR20190015715A (en) | 2019-02-14 |
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