SG10201603721TA - Anti-CTLA-4 Antibodies - Google Patents

Anti-CTLA-4 Antibodies

Info

Publication number
SG10201603721TA
SG10201603721TA SG10201603721TA SG10201603721TA SG10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA SG 10201603721T A SG10201603721T A SG 10201603721TA
Authority
SG
Singapore
Prior art keywords
ctla
antibodies
Prior art date
Application number
SG10201603721TA
Inventor
Cheng-I Wang
Eve Ngoh
Siok Ping Yeo
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Priority to SG10201603721TA priority Critical patent/SG10201603721TA/en
Priority to US15/486,468 priority patent/US9758583B2/en
Priority to AU2017262448A priority patent/AU2017262448A1/en
Priority to CA3023787A priority patent/CA3023787A1/en
Priority to JP2018559329A priority patent/JP6650537B2/en
Priority to SG11201809857TA priority patent/SG11201809857TA/en
Priority to EP17718870.3A priority patent/EP3455255B1/en
Priority to US16/099,652 priority patent/US11267887B2/en
Priority to CN201780029330.5A priority patent/CN109563165B/en
Priority to PCT/EP2017/058956 priority patent/WO2017194265A1/en
Priority to TW106112375A priority patent/TW201739763A/en
Priority to KR1020187035791A priority patent/KR20190015715A/en
Publication of SG10201603721TA publication Critical patent/SG10201603721TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0638Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70521CD28, CD152
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
SG10201603721TA 2016-05-10 2016-05-10 Anti-CTLA-4 Antibodies SG10201603721TA (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SG10201603721TA SG10201603721TA (en) 2016-05-10 2016-05-10 Anti-CTLA-4 Antibodies
US15/486,468 US9758583B2 (en) 2016-05-10 2017-04-13 Anti-CTLA-4 antibodies
AU2017262448A AU2017262448A1 (en) 2016-05-10 2017-04-13 Anti-CTLA-4 antibodies
CA3023787A CA3023787A1 (en) 2016-05-10 2017-04-13 Anti-ctla-4 antibodies
JP2018559329A JP6650537B2 (en) 2016-05-10 2017-04-13 Anti-CTLA-4 antibody
SG11201809857TA SG11201809857TA (en) 2016-05-10 2017-04-13 Anti-CTLA-4 Antibodies
EP17718870.3A EP3455255B1 (en) 2016-05-10 2017-04-13 Anti-ctla-4 antibodies
US16/099,652 US11267887B2 (en) 2016-05-10 2017-04-13 Anti-CTLA-4 antibodies
CN201780029330.5A CN109563165B (en) 2016-05-10 2017-04-13 anti-CTLA-4 antibodies
PCT/EP2017/058956 WO2017194265A1 (en) 2016-05-10 2017-04-13 Anti-CTLA-4 Antibodies
TW106112375A TW201739763A (en) 2016-05-10 2017-04-13 Anti-CTLA-4 antibodies
KR1020187035791A KR20190015715A (en) 2016-05-10 2017-04-13 Anti-CTLA-4 antibody

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201603721TA SG10201603721TA (en) 2016-05-10 2016-05-10 Anti-CTLA-4 Antibodies

Publications (1)

Publication Number Publication Date
SG10201603721TA true SG10201603721TA (en) 2017-12-28

Family

ID=58609383

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201603721TA SG10201603721TA (en) 2016-05-10 2016-05-10 Anti-CTLA-4 Antibodies
SG11201809857TA SG11201809857TA (en) 2016-05-10 2017-04-13 Anti-CTLA-4 Antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201809857TA SG11201809857TA (en) 2016-05-10 2017-04-13 Anti-CTLA-4 Antibodies

Country Status (10)

Country Link
US (2) US9758583B2 (en)
EP (1) EP3455255B1 (en)
JP (1) JP6650537B2 (en)
KR (1) KR20190015715A (en)
CN (1) CN109563165B (en)
AU (1) AU2017262448A1 (en)
CA (1) CA3023787A1 (en)
SG (2) SG10201603721TA (en)
TW (1) TW201739763A (en)
WO (1) WO2017194265A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2785692B1 (en) 2011-12-01 2017-09-27 ChemoCentryx, Inc. Substituted anilines as ccr(4) antagonists
ES2905525T3 (en) 2015-05-06 2022-04-11 Snipr Tech Ltd Alteration of microbial populations and modification of the microbiota
WO2016196237A1 (en) 2015-05-29 2016-12-08 Agenus Inc. Anti-ctla-4 antibodies and methods of use thereof
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
SG10201603721TA (en) * 2016-05-10 2017-12-28 Agency Science Tech & Res Anti-CTLA-4 Antibodies
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
MA50949B1 (en) 2016-12-07 2023-12-29 Memorial Sloan Kettering Cancer Center ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF
WO2019036855A1 (en) 2017-08-21 2019-02-28 Adagene Inc. Anti-cd137 molecules and use thereof
SG11202001604UA (en) * 2017-09-21 2020-04-29 Eucure Beijing Biopharma Co Ltd Anti-ctla4 antibodies and uses thereof
TWI800552B (en) 2017-11-10 2023-05-01 新加坡科技研究局 Il2rbeta/common gamma chain antibodies
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
WO2019148444A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Anti-ctla4 antibodies and methods of making and using the same
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
JP2021524282A (en) * 2018-05-17 2021-09-13 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Receptor inhibition by phosphatase mobilization
BR112021002928A2 (en) 2018-08-29 2021-05-11 Chemocentryx, Inc. combination therapy using c-c chemokine receptor 4 (ccr4) antagonists and one or more immunological checkpoint inhibitors
WO2020094834A1 (en) 2018-11-09 2020-05-14 Euchloe Bio Pte. Ltd. Il2rbeta/common gamma chain antibodies
WO2020094836A1 (en) 2018-11-09 2020-05-14 Euchloe Bio Pte. Ltd. Il2rbeta/common gamma chain antibodies
BR112021012037A2 (en) 2018-12-21 2021-11-03 Ose Immunotherapeutics Bifunctional anti-pd-1/il-7 molecule
IL316757A (en) * 2018-12-27 2025-01-01 Gigagen Inc Anti-ctla-4 binding proteins and methods of use thereof
WO2020165374A1 (en) 2019-02-14 2020-08-20 Ose Immunotherapeutics Bifunctional molecule comprising il-15ra
CN110343180B (en) * 2019-07-25 2021-03-30 北京免疫方舟医药科技有限公司 anti-CTLA-4 antibodies and uses thereof
WO2021122866A1 (en) 2019-12-17 2021-06-24 Ose Immunotherapeutics Bifunctional molecules comprising an il-7 variant
AU2021287376A1 (en) * 2020-06-11 2022-12-15 Nantbio, Inc. Anti-CTLA4 monoclonal antibodies and chimeric antigen receptors
KR20230033719A (en) * 2020-07-02 2023-03-08 기가젠, 인코포레이티드 Anti-CTLA-4 binding proteins and methods of use thereof
WO2022112198A1 (en) 2020-11-24 2022-06-02 Worldwide Innovative Network Method to select the optimal immune checkpoint therapies
KR20220112208A (en) * 2021-02-03 2022-08-10 주식회사 유틸렉스 Anti-CTLA-4 antibody and uses thereof
RU2757418C1 (en) * 2021-03-04 2021-10-15 федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный университет" Tetradecapeptide antagonist of interaction ctla-4 with b7-1
IL307419A (en) 2021-04-09 2023-12-01 Ose Immunotherapeutics New scaffold for bifunctional molecules with improved properties
US20240182572A1 (en) 2021-04-09 2024-06-06 Ose Immunotherapeutics Scaffold for bifunctional molecules comprising pd-1 or cd28 and sirp binding domains
GB202209518D0 (en) 2022-06-29 2022-08-10 Snipr Biome Aps Treating & preventing E coli infections
WO2024003360A1 (en) 2022-07-01 2024-01-04 Institut Curie Biomarkers and uses thereof for the treatment of neuroblastoma
WO2024028386A1 (en) 2022-08-02 2024-02-08 Ose Immunotherapeutics Multifunctional molecule directed against cd28
WO2024200823A1 (en) 2023-03-30 2024-10-03 Ose Immunotherapeutics Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof
WO2024200826A1 (en) 2023-03-30 2024-10-03 Ose Immunotherapeutics Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell inhibiting molecule and use thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE311895T1 (en) 1992-05-26 2005-12-15 Immunex Corp NEW CYTOKINE THAT BINDS CD30
PT1212422E (en) 1999-08-24 2007-04-30 Medarex Inc Human ctla-4 antibodies and their uses
ITRM20010408A1 (en) 2001-07-10 2003-01-10 Univ Napoli Federico Ii CYTOTOXIC HUMAN MINI-ANTIBODY FOR CANCER CELLS THAT EXPRESS THE ERBB2 RECEPTOR.
BR0306808A (en) 2002-01-09 2005-08-30 Medarex Inc Human Monoclonal Antibodies against cd30
SI2511297T1 (en) 2004-02-06 2015-07-31 Morphosys Ag Anti-CD38 human antibodies and uses therefor
PL2287195T3 (en) 2004-07-01 2019-10-31 Novo Nordisk As Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy
EP3153525A1 (en) 2005-03-23 2017-04-12 Genmab A/S Antibodies against cd38 for treatment of multiple myeloma
AU2006244885B2 (en) 2005-05-09 2011-03-31 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
TWI461436B (en) 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd Human monoclonal antibody human cd134 (ox40) and methods of making and using same
DK2511301T3 (en) 2006-08-04 2018-03-12 Medimmune Ltd HUMAN ANTIBODIES AGAINST ERBB 2
EP2087114B1 (en) 2006-11-13 2013-05-29 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Methods of treating cancer using sirna molecules directed against cd24
DK2716301T3 (en) 2007-02-16 2017-07-31 Merrimack Pharmaceuticals Inc ANTIBODIES AGAINST ERBB3 AND APPLICATIONS THEREOF
AR069747A1 (en) 2007-11-30 2010-02-17 Medarex Inc ANTI-B7H4 MONOCLONAL ANTIBODY CONJUGATE - PHARMACO AND METHODS OF USE
EP4331604B1 (en) 2008-12-09 2025-03-05 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
EP3009455A1 (en) 2009-09-16 2016-04-20 Immunomedics Inc. Class i anti-cea antibodies and uses thereof
ME03447B (en) 2010-03-04 2020-01-20 Macrogenics Inc ANTIBODIES REACTING WITH B7-H3, ASSOCIATED IMMUNOLOGICALLY ACTIVE FRAGMENTS AND ASSOCIATED USES
CA2800488A1 (en) 2010-05-26 2011-12-01 Regents Of The University Of Minnesota Single-chain variable fragment anti-cd133 antibodies and uses thereof
EA031849B1 (en) 2010-08-23 2019-03-29 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Anti-ox40 antibodies and methods of using the same
SI2703486T1 (en) 2011-04-25 2018-05-31 Daiichi Sankyo Company, Limited Anti-b7-h3 antibody
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
US8791244B2 (en) 2011-09-30 2014-07-29 Regeneron Pharmaceuticals, Inc. Anti-ErbB3 antibodies and uses thereof
ES2861435T3 (en) 2011-11-03 2021-10-06 Univ Pennsylvania Specific compositions of isolated B7-H4 and methods of using them
CN109793893B (en) 2012-09-07 2023-05-26 达特茅斯大学理事会 VISTA modulators for diagnosis and treatment of cancer
EP2912063A1 (en) 2012-10-23 2015-09-02 Bristol-Myers Squibb Company Combination of anti-kir and anti-ctla-4 antibodies to treat cancer
SG11201504764SA (en) 2012-12-19 2015-07-30 Amplimmune Inc Anti-human b7-h4 antibodies and their uses
US9573988B2 (en) 2013-02-20 2017-02-21 Novartis Ag Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
WO2014160627A1 (en) 2013-03-25 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd276 polypeptides, proteins, and chimeric antigen receptors
SMT201900332T1 (en) 2013-09-20 2019-07-11 Bristol Myers Squibb Co Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors
DK3087098T3 (en) 2013-12-24 2020-06-08 Janssen Pharmaceutica Nv Anti-Vista antibodies and fragments
CN104974253A (en) * 2014-04-01 2015-10-14 上海中信国健药业股份有限公司 Anti-CTLA-4/PD-1 bispecific antibody as well as preparation method and application thereof
SG10201603721TA (en) * 2016-05-10 2017-12-28 Agency Science Tech & Res Anti-CTLA-4 Antibodies

Also Published As

Publication number Publication date
US11267887B2 (en) 2022-03-08
TW201739763A (en) 2017-11-16
US20170226211A1 (en) 2017-08-10
WO2017194265A1 (en) 2017-11-16
CN109563165A (en) 2019-04-02
JP2019519208A (en) 2019-07-11
CA3023787A1 (en) 2017-11-16
CN109563165B (en) 2020-09-25
AU2017262448A1 (en) 2019-01-03
JP6650537B2 (en) 2020-02-19
SG11201809857TA (en) 2018-12-28
EP3455255A1 (en) 2019-03-20
EP3455255B1 (en) 2021-03-03
US9758583B2 (en) 2017-09-12
US20190153097A1 (en) 2019-05-23
KR20190015715A (en) 2019-02-14

Similar Documents

Publication Publication Date Title
HUS2500002I1 (en) Novel anti-pd-l1 antibodies
ZA201900353B (en) Anti-pd-l1 antibodies
IL262295A (en) Anti-pd-l1 antibodies
IL264159A (en) Anti-tim-3 antibodies
HK1246324A1 (en) Anti-pd-l1 antibodies
SG10201603721TA (en) Anti-CTLA-4 Antibodies
IL255727A (en) Novel anti-pd-l1 antibodies
SMT202000691T1 (en) Anti-pd-1 antibodies
SG10201601719RA (en) Anti-LAG-3 Antibodies
GB201601073D0 (en) Antibodies
GB201621439D0 (en) IL-11Ra Antibodies
ZA201901865B (en) Anti-pd-1 antibodies
GB201610044D0 (en) Antibodies
GB201603291D0 (en) Antibodies
GB201616699D0 (en) Antibodies
IL264262A (en) Anti-il-22r antibodies
IL263406B1 (en) Anti-tnfrsf25 antibodies
GB201622197D0 (en) Antibodies
GB201620414D0 (en) Antibodies
GB201615224D0 (en) Antibodies
GB201613158D0 (en) Antibodies
GB201612437D0 (en) Anti-lag-3 antibodies