Review
doi: 10.1016/s0167-7799(98)01245-1.
Proteomics: quantitative and physical mapping of cellular proteins
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- PMID: 10189717
- DOI: 10.1016/s0167-7799(98)01245-1
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Review
Proteomics: quantitative and physical mapping of cellular proteins
Trends Biotechnol.
1999 Mar.
Abstract
Genome sequencing provides a wealth of information on predicted gene products (mostly proteins), but the majority of these have no known function. Two-dimensional gel electrophoresis and mass spectrometry have, coupled with searches in protein and EST databases, transformed the protein-identification process. The proteome is the expressed protein complement of a genome and proteomics is functional genomics at the protein level. Proteomics can be divided into expression proteomics, the study of global changes in protein expression, and cell-map proteomics, the systematic study of protein-protein interactions through the isolation of protein complexes.
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