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. 1999 Oct 22;274(43):30686-9.
doi: 10.1074/jbc.274.43.30686.

Activation of interferon regulatory factor 3 in response to DNA-damaging agents

T Kim  1 , T Y Kim, Y H Song, I M Min, J Yim, T K Kim
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Free article

Activation of interferon regulatory factor 3 in response to DNA-damaging agents

T Kim et al. J Biol Chem. .
Free article

Abstract

Genotoxic stress triggers signal transduction pathways that mediate either the protection or apoptosis of affected cells. The interferon regulatory factors (IRFs) are involved in a wide range of host defense mechanisms against environmental stresses. Treatment with DNA-damaging agents, including doxorubicin and UV radiation, caused phosphorylation of the IRF3 transcription factor. Phosphorylation of IRF3 induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein. Furthermore, genotoxic stress-induced phosphorylation of IRF3 resulted in its movement from the cytoplasm to the nucleus, where it activated transcription from its binding site. These observations suggest that IRF3 plays a role in the defensive responses induced by genotoxic stress.

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