Impact of sleep debt on metabolic and endocrine function
- PMID: 10543671
- DOI: 10.1016/S0140-6736(99)01376-8
Impact of sleep debt on metabolic and endocrine function
Abstract
Background: Chronic sleep debt is becoming increasingly common and affects millions of people in more-developed countries. Sleep debt is currently believed to have no adverse effect on health. We investigated the effect of sleep debt on metabolic and endocrine functions.
Methods: We assessed carbohydrate metabolism, thyrotropic function, activity of the hypothalamo-pituitary-adrenal axis, and sympathovagal balance in 11 young men after time in bed had been restricted to 4 h per night for 6 nights. We compared the sleep-debt condition with measurements taken at the end of a sleep-recovery period when participants were allowed 12 h in bed per night for 6 nights.
Findings: Glucose tolerance was lower in the sleep-debt condition than in the fully rested condition (p<0.02), as were thyrotropin concentrations (p<0.01). Evening cortisol concentrations were raised (p=0.0001) and activity of the sympathetic nervous system was increased in the sleep-debt condition (p<0.02).
Interpretation: Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function. The effects are similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
Similar articles
-
Sleep as a mediator of the relationship between socioeconomic status and health: a hypothesis.Ann N Y Acad Sci. 1999;896:254-61. doi: 10.1111/j.1749-6632.1999.tb08120.x. Ann N Y Acad Sci. 1999. PMID: 10681902
-
Electroencephalographic sleep profiles and hypothalamic-pituitary-adrenocortical (HPA)-activity in kindergarten children: early indication of poor sleep quality associated with increased cortisol secretion.J Psychiatr Res. 2008 Jun;42(7):532-43. doi: 10.1016/j.jpsychires.2007.05.010. Epub 2007 Jul 23. J Psychiatr Res. 2008. PMID: 17645894
-
Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling.Psychoneuroendocrinology. 2013 Jan;38(1):155-65. doi: 10.1016/j.psyneuen.2012.05.015. Epub 2012 Jul 7. Psychoneuroendocrinology. 2013. PMID: 22776420 Clinical Trial.
-
Metabolic and endocrine effects of sleep deprivation.Essent Psychopharmacol. 2005;6(6):341-7. Essent Psychopharmacol. 2005. PMID: 16459757 Review.
-
Restricted and disrupted sleep: effects on autonomic function, neuroendocrine stress systems and stress responsivity.Sleep Med Rev. 2008 Jun;12(3):197-210. doi: 10.1016/j.smrv.2007.07.007. Epub 2008 Jan 25. Sleep Med Rev. 2008. PMID: 18222099 Review.
Cited by
-
Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues.BMC Genomics. 2013 May 30;14:362. doi: 10.1186/1471-2164-14-362. BMC Genomics. 2013. PMID: 23721503 Free PMC article.
-
Functional capacity is a better predictor of coronary heart disease than depression or abnormal sleep duration in Black and White Americans.Sleep Med. 2012 Jun;13(6):728-31. doi: 10.1016/j.sleep.2012.01.015. Epub 2012 Mar 31. Sleep Med. 2012. PMID: 22465451 Free PMC article.
-
Obstructive sleep apnea is a predictor of abnormal glucose metabolism in chronically sleep deprived obese adults.PLoS One. 2013 May 29;8(5):e65400. doi: 10.1371/journal.pone.0065400. Print 2013. PLoS One. 2013. PMID: 23734252 Free PMC article. Clinical Trial.
-
Associations between sleep duration and cardiovascular diseases: A meta-review and meta-analysis of observational and Mendelian randomization studies.Front Cardiovasc Med. 2022 Aug 11;9:930000. doi: 10.3389/fcvm.2022.930000. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36035915 Free PMC article.
-
Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder.Sleep Med Rev. 2013 Aug;17(4):241-54. doi: 10.1016/j.smrv.2012.09.005. Epub 2013 Feb 16. Sleep Med Rev. 2013. PMID: 23419741 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
