Review
doi: 10.1016/s0167-4838(00)00158-8.
Glycodelin: a reproduction-related lipocalin
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- PMID: 11058757
- DOI: 10.1016/s0167-4838(00)00158-8
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Review
Glycodelin: a reproduction-related lipocalin
Biochim Biophys Acta.
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Abstract
Glycodelin, a human lipocalin, is a major endometrial protein with at least two differentially glycosylated isoforms. Glycodelin-A (GdA) is purified from human mid-trimester amniotic fluid, where it is secreted from the decidualized endometrium. Glycodelin-S (GdS) is synthesized in the male reproductive tract, mainly in the seminal vesicles, and secreted into seminal plasma. These two glycodelin isoforms, glycosylated in a completely different manner, serve as a good model for studying the effects of glycosylation on protein function and physicochemical properties. We have reviewed here the structure, expression and biological functions of glycodelin.
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