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Comparative Study
. 2001 Jun;79(2):199-207.
doi: 10.1023/a:1010246401056.

Comparison of yoghurt, heat treated yoghurt, milk and lactose effects on plasmid dissemination in gnotobiotic mice

S Maisonneuve  1 , M F Ouriet, Y Duval-Iflah
Affiliations
Comparative Study

Comparison of yoghurt, heat treated yoghurt, milk and lactose effects on plasmid dissemination in gnotobiotic mice

S Maisonneuve et al. Antonie Van Leeuwenhoek. 2001 Jun.

Abstract

The effect of yoghurt, heat-treated fermented milk, milk and lactose solution intake on plasmid transfer and establishment of the resulting transconjugants in the digestive tract of mice colonised with human faecal flora were examined. Yoghurt lowered the population level of transconjugants more efficiently than heat-treated fermented milk (-2 log and -1 log respectively) and indicated a beneficial effect of viable bacteria. On the other hand consumption of milk drastically inhibited the establishment of transconjugants, which were below the detection threshold of 10(2) UFC per g of faeces. We were not able to recover transconjugants from faecal samples with lactose supplementation, indicating a possible inhibition of plasmid transfer. Since the yoghurt, heat-treated fermented milk, milk and lactose solution contained approximately the same lactose concentration it is fair to speculate that lactose may contribute to the inhibiting effects of the various supplementations. The inhibitions described were not associated with other intestinal parameters like the intestinal transit time, the population levels of the recipient, or the donor and total anaerobic microflora. It is evident that other parameters need to be investigated such as the composition of the endogenous microflora and metabolic products.

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