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Comparative Study
. 2004 Jul 19;91(2):258-61.
doi: 10.1038/sj.bjc.6601952.

Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma

F Lemaire  1 , R Millon, D Muller, Y Rabouel, L Bracco, J Abecassis, B Wasylyk
Affiliations
Comparative Study

Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma

F Lemaire et al. Br J Cancer. .

Abstract

We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).

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Figures

Figure 1
Figure 1
Analysis of HOP RNA expression by Virtual Northern blots (A) and Northern blots (B). Bars indicate tumour (T) and normal (N) samples from the same patients. Comparisons should be made between matched samples. RPLP0 is the loading control.
Figure 2
Figure 2
Real-time quantitative RT–PCR. (A, B) Traces and standard curves of HOP (A) and RPLP0 (B) analysis for tumour samples (full line) and normal samples (long dotted line). Control without cDNA (short dotted line). (C). HOP expression was analysed in 33 hypopharyngeal tumours and 23 matched normal samples by RT–QPCR. HOP expression values were calculated in relative units adjusted to the RPLP0 internal controls. Statistical analysis between tumour and normal samples, and between tumours according to their histopathological differentiation status, were carried out by ANOVA statistical tests.
Figure 3
Figure 3
In situ hybridisation of normal tissue. The uvula was hybridised with an antisense probe (A) or stained with haematoxylin/eosin (B). The black arrowhead indicates the specific stain and the white arrowhead the basal layer. The bars represent 50 μm.
See this image and copyright information in PMC

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