doi: 10.1016/j.expneurol.2004.03.026.
BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells
Affiliations
- PMID: 15246821
- DOI: 10.1016/j.expneurol.2004.03.026
Item in Clipboard
BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells
Exp Neurol.
2004 Aug.
Abstract
Bone morphogenetic proteins (BMPs) have an important role in neuronal and astrocytic differentiation of embryonic and adult neural stem cells (NSCs). Here, we show that BMP6, BMP7, GDF5, and GDF6 instructively differentiate E12, E14, and E17 rat cortical NSCs into a variety of neural crest lineages. Clonal analysis shows that BMP7-treated NSCs develop mostly into smooth muscle and peripheral glia. We observed a rapid induction of premigratory neural crest markers like p75NTR, and AP-2 alpha followed by Msx1, Msx2, and Slug, transcription factors that participate in neural crest development. These results suggest that NSCs cultured in vitro in the presence of FGF2 display expanded developmental potential.
Similar articles
-
BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.J Cell Biol. 2003 Jun 9;161(5):911-21. doi: 10.1083/jcb.200211021. J Cell Biol. 2003. PMID: 12796477 Free PMC article.
-
Postmigratory enteric and sympathetic neural precursors share common, developmentally regulated, responses to BMP2.Dev Biol. 2000 Nov 1;227(1):1-11. doi: 10.1006/dbio.2000.9876. Dev Biol. 2000. PMID: 11076672
-
Wnts and the neural crest.Anat Embryol (Berl). 2005 Jun;209(5):349-55. doi: 10.1007/s00429-005-0459-9. Epub 2005 May 13. Anat Embryol (Berl). 2005. PMID: 15891909 Review.
-
A common neural progenitor for the CNS and PNS.Dev Biol. 1998 Aug 1;200(1):1-15. doi: 10.1006/dbio.1998.8913. Dev Biol. 1998. PMID: 9698451
-
Neural stem cells in mammalian development.Curr Opin Cell Biol. 2006 Dec;18(6):704-9. doi: 10.1016/j.ceb.2006.09.008. Epub 2006 Oct 12. Curr Opin Cell Biol. 2006. PMID: 17046226 Review.
Cited by
-
The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation.Dev Neurobiol. 2012 Jul;72(7):1068-84. doi: 10.1002/dneu.22022. Dev Neurobiol. 2012. PMID: 22489086 Free PMC article. Review.
-
Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells.PLoS One. 2012;7(8):e43797. doi: 10.1371/journal.pone.0043797. Epub 2012 Aug 22. PLoS One. 2012. PMID: 22928036 Free PMC article.
-
A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.Stem Cells Dev. 2019 Jan 15;28(2):81-100. doi: 10.1089/scd.2017.0234. Epub 2018 Dec 18. Stem Cells Dev. 2019. PMID: 30375284 Free PMC article.
-
Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain.Front Neurosci. 2016 Aug 29;10:373. doi: 10.3389/fnins.2016.00373. eCollection 2016. Front Neurosci. 2016. PMID: 27621700 Free PMC article.
-
Schwann cell-like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP-dependent.Glia. 2006 Aug 15;54(3):147-59. doi: 10.1002/glia.20369. Glia. 2006. PMID: 16921543 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
