Prefrontal neurons coding suppression of specific saccades
- PMID: 15294148
- DOI: 10.1016/j.neuron.2004.07.013
Prefrontal neurons coding suppression of specific saccades
Abstract
The prefrontal cortex has been implicated in the suppression of unwanted behavior, based upon observations of humans and monkeys with prefrontal lesions. Despite this, there has been little direct neurophysiological evidence for a mechanism that suppresses specific behavior. In this study, we used an oculomotor delayed match/nonmatch-to-sample task in which monkeys had to remember a stimulus location either as a marker of where to look or as a marker of where not to look. We found a group of neurons in both the frontal eye field and the caudal prefrontal cortex that carried signals selective for the forbidden stimulus. The activity of these "don't look" neurons correlated with the monkeys' success or failure on the task. These results demonstrate a frontal signal that is related to the active suppression of one action while the subject performs another.
Copyright 2004 Cell Press
Comment in
-
Don't go there.Neuron. 2004 Aug 5;43(3):297-9. doi: 10.1016/j.neuron.2004.07.021. Neuron. 2004. PMID: 15294137 Review.
Similar articles
-
Macaque dorsolateral prefrontal cortex does not suppress saccade-related activity in the superior colliculus.Cereb Cortex. 2014 May;24(5):1373-88. doi: 10.1093/cercor/bhs424. Epub 2013 Jan 10. Cereb Cortex. 2014. PMID: 23307633
-
Rule-dependent activity for prosaccades and antisaccades in the primate prefrontal cortex.J Cogn Neurosci. 2005 Sep;17(9):1483-96. doi: 10.1162/0898929054985455. J Cogn Neurosci. 2005. PMID: 16197701
-
Neuronal activity related to elapsed time in prefrontal cortex.J Neurophysiol. 2006 May;95(5):3281-5. doi: 10.1152/jn.01011.2005. Epub 2006 Jan 18. J Neurophysiol. 2006. PMID: 16421197 Free PMC article.
-
Contributions of prefrontal cue-, delay-, and response-period activity to the decision process of saccade direction in a free-choice ODR task.Neural Netw. 2006 Oct;19(8):1203-22. doi: 10.1016/j.neunet.2006.05.033. Epub 2006 Aug 30. Neural Netw. 2006. PMID: 16942859
-
Control of the superior colliculus by the lateral prefrontal cortex.Philos Trans R Soc Lond B Biol Sci. 2013 Sep 9;368(1628):20130068. doi: 10.1098/rstb.2013.0068. Print 2013 Oct 19. Philos Trans R Soc Lond B Biol Sci. 2013. PMID: 24018729 Free PMC article. Review.
Cited by
-
Efficacy of inhibitory control depends on procrastination and deceleration in saccade planning.Exp Brain Res. 2020 Oct;238(10):2417-2432. doi: 10.1007/s00221-020-05901-z. Epub 2020 Aug 9. Exp Brain Res. 2020. PMID: 32776172
-
Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degeneration.J Neurosci. 2006 Jun 7;26(23):6354-63. doi: 10.1523/JNEUROSCI.0549-06.2006. J Neurosci. 2006. PMID: 16763044 Free PMC article.
-
Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements.J Neurosci. 2007 Sep 12;27(37):9893-900. doi: 10.1523/JNEUROSCI.2837-07.2007. J Neurosci. 2007. PMID: 17855604 Free PMC article.
-
Motor synchronization and impulsivity in pediatric borderline personality disorder with and without attention-deficit hyperactivity disorder: an eye-tracking study of saccade, blink and pupil behavior.Front Neurosci. 2023 Jun 22;17:1179765. doi: 10.3389/fnins.2023.1179765. eCollection 2023. Front Neurosci. 2023. PMID: 37425020 Free PMC article.
-
Intermittent rate coding and cue-specific ensembles support working memory.Nature. 2024 Dec;636(8042):422-429. doi: 10.1038/s41586-024-08139-9. Epub 2024 Nov 6. Nature. 2024. PMID: 39506106 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
