Review
doi: 10.1111/j.0022-202X.2005.23627.x.
Transglutaminase function in epidermis
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- PMID: 15737187
- DOI: 10.1111/j.0022-202X.2005.23627.x
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Review
Transglutaminase function in epidermis
J Invest Dermatol.
2005 Mar.
Free article
Abstract
Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.
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