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Comparative Study
. 1991 Oct 15;88(20):8900-4.
doi: 10.1073/pnas.88.20.8900.

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

M A Kennedy  1 , R Gonzalez-Sarmiento, U R Kees, F Lampert, N Dear, T Boehm, T H Rabbitts
Affiliations
Comparative Study

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

M A Kennedy et al. Proc Natl Acad Sci U S A. .

Abstract

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

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