Review
doi: 10.1038/nrm2163.
Epub 2007 Apr 11.
The spindle-assembly checkpoint in space and time
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- PMID: 17426725
- DOI: 10.1038/nrm2163
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Review
The spindle-assembly checkpoint in space and time
Nat Rev Mol Cell Biol.
2007 May.
Abstract
In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores--structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
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