doi: 10.1016/0888-7543(91)90124-w.
The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24
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- PMID: 1765382
- DOI: 10.1016/0888-7543(91)90124-w
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The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24
Genomics.
1991 Sep.
Abstract
FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent x human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.
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