A review of the use of adapalene for the treatment of acne vulgaris

. 2007 Aug;3(4):621-4.

A review of the use of adapalene for the treatment of acne vulgaris

Suleyman Piskin¹, Erol Uzunali

Affiliations

PMID: 18472984
PMCID: PMC2374937

A review of the use of adapalene for the treatment of acne vulgaris

Suleyman Piskin et al. Ther Clin Risk Manag. 2007 Aug.

. 2007 Aug;3(4):621-4.

Authors

Suleyman Piskin¹, Erol Uzunali

Affiliation

¹ Trakya University, Faculty of Medicine, Department of Dermatology Edirne, Turkey.

PMID: 18472984
PMCID: PMC2374937

Abstract

Acne is a disease of the pilosebaceous unit with involving abnormalities in sebum production, microbial flora changes, abnormal keratinization, and inflammation. There are several therapeutic options like topical and systemic retinoids, antibiotics, and systemic hormonal drugs. The topical retinoids a play very important role in the treatment of acne vulgaris. However, their use is limited due to skin irritation. A new generation product, adapalene is a good choice in the treatment of acne vulgaris with less side effects and high efficacy confirmed by numerous clinical studies.

Keywords: acne vulgaris; adapalene; treatment.

PubMed Disclaimer

Figures

**Figure 1**
Structural formula of adapalene.

See this image and copyright information in PMC

Cited by

Letter to the editor: comparative efficacy and safety of clindamycin phosphate/benzoyl peroxide and adapalene/benzoyl peroxide in acne treatment: a systematic review and meta-analysis of randomized controlled trials.
Sesgundo JA, Borra UR, Teslim AA, Hikal H, Qammar A, Adams D, Serag I. Sesgundo JA, et al. Arch Dermatol Res. 2024 Sep 3;316(8):595. doi: 10.1007/s00403-024-03346-w. Arch Dermatol Res. 2024. PMID: 39225838 No abstract available.
Formulation and evaluation of Adapalene-loaded nanoparticulates for epidermal localization.
Bhalekar M, Upadhaya P, Madgulkar A. Bhalekar M, et al. Drug Deliv Transl Res. 2015 Dec;5(6):585-95. doi: 10.1007/s13346-015-0261-z. Drug Deliv Transl Res. 2015. PMID: 26483036
Efficacy and Safety of Tazarotene 0.1% Plus Clindamycin 1% Gel Versus Adapalene 0.1% Plus Clindamycin 1% Gel in Facial Acne Vulgaris: A Randomized, Controlled Clinical Trial.
Maiti R, Sirka CS, Ashique Rahman MA, Srinivasan A, Parida S, Hota D. Maiti R, et al. Clin Drug Investig. 2017 Nov;37(11):1083-1091. doi: 10.1007/s40261-017-0568-2. Clin Drug Investig. 2017. PMID: 28913735 Clinical Trial.
The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study.
Treesirichod A, Chaithirayanon S, Wongjitrat N, Wattanapan P. Treesirichod A, et al. Indian J Dermatol. 2015 Jan-Feb;60(1):103. doi: 10.4103/0019-5154.147838. Indian J Dermatol. 2015. PMID: 25657419 Free PMC article.
Screening of Adapalene Microsponges Fabrication Parameters with Insight on the In vitro Biological Effectiveness.
Yehia RM, Attia DA, Elmazar MM, El-Nabarawi MA, Teaima MH. Yehia RM, et al. Drug Des Devel Ther. 2022 Nov 4;16:3847-3864. doi: 10.2147/DDDT.S383051. eCollection 2022. Drug Des Devel Ther. 2022. PMID: 36388080 Free PMC article.

See all "Cited by" articles

References

1. Bergfeld WF. The evolving role of retinoids in the management of cutaneous conditions. Clinician. 1998;16:1–32.
1. Bershad S, Kranjac Singer GK, Parente JE, et al. Successful treatment of acne vulgaris using a new method: results of a randomized vehicle-controlled trial of short-contact therapy with 0.1% tazarotene gel. Arch Dermatol. 2002;138:481–9. - PubMed
1. Brand B, Gilbert R, Baker MD, et al. Cumulative irritancy comparision of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents. J Am Acad Dermatol. 2003;49:S227–32. - PubMed
1. Braun-Falco O, Plewig G, Wolff HH, et al. Dermatology. 2. Berlin: Springer-Verlag; 2001.
1. Cunliffe WJ, Caputo R, Dreno B, et al. Clinical efficacy and safety comparision of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials. J Am Acad Dermatol. 1997;36:S126–34. - PubMed

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database

[1] Bergfeld WF. The evolving role of retinoids in the management of cutaneous conditions. Clinician. 1998;16:1–32.

[2] Bergfeld WF. The evolving role of retinoids in the management of cutaneous conditions. Clinician. 1998;16:1–32.

[3] Bershad S, Kranjac Singer GK, Parente JE, et al. Successful treatment of acne vulgaris using a new method: results of a randomized vehicle-controlled trial of short-contact therapy with 0.1% tazarotene gel. Arch Dermatol. 2002;138:481–9. - PubMed

[4] Bershad S, Kranjac Singer GK, Parente JE, et al. Successful treatment of acne vulgaris using a new method: results of a randomized vehicle-controlled trial of short-contact therapy with 0.1% tazarotene gel. Arch Dermatol. 2002;138:481–9. - PubMed

[5] Brand B, Gilbert R, Baker MD, et al. Cumulative irritancy comparision of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents. J Am Acad Dermatol. 2003;49:S227–32. - PubMed

[6] Brand B, Gilbert R, Baker MD, et al. Cumulative irritancy comparision of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents. J Am Acad Dermatol. 2003;49:S227–32. - PubMed

[7] Braun-Falco O, Plewig G, Wolff HH, et al. Dermatology. 2. Berlin: Springer-Verlag; 2001.

[8] Braun-Falco O, Plewig G, Wolff HH, et al. Dermatology. 2. Berlin: Springer-Verlag; 2001.

[9] Cunliffe WJ, Caputo R, Dreno B, et al. Clinical efficacy and safety comparision of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials. J Am Acad Dermatol. 1997;36:S126–34. - PubMed

[10] Cunliffe WJ, Caputo R, Dreno B, et al. Clinical efficacy and safety comparision of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials. J Am Acad Dermatol. 1997;36:S126–34. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A review of the use of adapalene for the treatment of acne vulgaris

Affiliation

A review of the use of adapalene for the treatment of acne vulgaris

Authors

Affiliation

Abstract

Figures

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Figures

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources