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. 1993 Mar;64(3):898-902.
doi: 10.1016/S0006-3495(93)81450-4.

Modification of supported lipid membranes by atomic force microscopy

S L Brandow  1 , D C Turner, B R Ratna, B P Gaber
Affiliations

Modification of supported lipid membranes by atomic force microscopy

S L Brandow et al. Biophys J. 1993 Mar.

Abstract

The atomic force microscope (AFM) was used to structurally modify supported lipid bilayers in a controlled quantitative manner. By increasing the force applied by the AFM tip, lipid was removed from the scanned area, leaving a cut through the lipid bilayer. Cuts were repaired with the AFM by scanning the region with a controlled force and driving lipid back into the cut. A slow self-annealing of cuts was also observed.

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