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. 2010 Mar;127(3):287-94.
doi: 10.1007/s00439-009-0768-9.

The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders

Takuro Furusawa  1 , Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Tsukasa Inaoka, Yasuhiro Matsumura, Yuji Ataka, Nao Nishida, Naoyuki Tsuchiya, Ryutaro Ohtsuka, Jun Ohashi
Affiliations

The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders

Takuro Furusawa et al. Hum Genet. 2010 Mar.

Abstract

Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI > or = 30) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P = 0.0009) and BMI (P = 0.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a signiWcantly higher risk of obesity in comparison to non-carriers (P = 0.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations.

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