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. 2010 Oct 21;29(1):136.
doi: 10.1186/1756-9966-29-136.

CIP2A expression is increased in prostate cancer

Markku H Vaarala  1 , Marja-Riitta Väisänen, Ari Ristimäki
Affiliations

CIP2A expression is increased in prostate cancer

Markku H Vaarala et al. J Exp Clin Cancer Res. .

Abstract

Background: The CIP2A protein is a recently characterized oncoprotein which inhibits protein phosphatase 2A activity. Expression of CIP2A has been detected in several carcinomas, but its expression and significance in prostate cancer has not been examined so far.

Methods: Expression of the CIP2A protein was studied using immunohistochemistry in prostate cancer (n = 59) and in benign prostatic hyperplasia (n = 20) specimens. The CIP2A staining scores were compared with several clinicopathological parameters.

Results: Expression of CIP2A was increased in prostate cancer epithelium as compared with the benign hyperplastic epithelium (p < 0.001). The expression of CIP2A was associated with high Gleason scores (p < 0.001) and among patients treated with radical prostatectomy, CIP2A expression was associated with pre-treatment risk stratification (p = 0.011) and pathological T-class (p = 0.031). No statistically significant association was detected between CIP2A expression and prostate specific antigen concentrations.

Conclusions: Expression of the CIP2A protein is increased in prostate cancer specimens and its expression is associated with poorly differentiated and high-risk tumors.

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Figures

Figure 1
Figure 1
Expression of CIP2A in benign prostatic hyperplasia and in prostate cancer. Immunohistochemical detection of CIP2A protein expression in benign prostatic hyperplasia specimens (A) and in prostate cancer specimens (B-C). The representative Gleason scores of 6 (B) and 9 (C) are presented. Diffuse, weak cytoplasmic staining of CIP2A was present in hyperplastic tissues, whereas the staining pattern in cancer cells showed coarsely granular cytoplasmic positivity. Magnification × 100, and in inserts × 400.
See this image and copyright information in PMC

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