doi: 10.1016/0014-5793(90)80583-5.
One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta
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- PMID: 2178974
- DOI: 10.1016/0014-5793(90)80583-5
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One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta
FEBS Lett.
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Abstract
A cDNA encoding human endothelin 3 (ET-3) precursor was cloned from a cDNA library from the placenta, and its nucleotide and deduced amino acid sequences were determined. This ET-3 cDNA was found to contain 2.3 kb pairs and encode prepro-ET-3 protein consisting of 224 amino acid residues. The putative big-ET-3 seems to consist of 42 amino acid residues. Two of the intron insertion sites were determined with information from nucleotide sequences of the cloned genomic ET-3 gene. This is the first direct evidence that the ET-3 gene is transcribed and expressed in the placenta.
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