As pressure on water resources increases, alternative practices to conserve water in paddies have been developed. Few studies have simultaneously examined the effectiveness of different water regimes on conserving water, mitigating greenhouse gases (GHG), and maintaining yields in rice production. This study, which was conducted during the drought of 2013, examined all three factors using a split-plot experiment with two rice varieties in a no-till paddy managed under three different water regimes: 1) continuous flooding (CF), 2) flooded and wet intermittent irrigation (FWI), and 3) flooded and dry intermittent irrigation (FDI). The Methane (CH₄) and nitrous oxide (N₂O) emissions were measured using static chamber-gas measurements, and the carbon dioxide (CO₂) emissions were monitored using a soil CO₂ flux system (LI-8100). Compared with CF, FWI and FDI irrigation strategies reduced CH₄ emissions by 60% and 83%, respectively. In contrast, CO₂ and N₂O fluxes increased by 65% and 9%, respectively, under FWI watering regime and by 104% and 11%, respectively, under FDI managed plots. Although CO₂ and N₂O emissions increased, the global warming potential (GWP) and greenhouse gas intensity (GHGI) of all three GHG decreased by up to 25% and 29% (p<0.01), respectively, using water-saving irrigation strategies. The rice variety also affected yields and GHG emissions in response to different water regimes. The drought-resistance rice variety (HY3) was observed to maintain yields, conserve water, and reduce GHG under the FWI irrigation management compared with the typical variety (FYY299) planted in the region. The FYY299 only had significantly lower GWP and GHGI when the yield was reduced under FDI water regime. In conclusion, FWI irrigation strategy could be an effective option for simultaneously saving water and mitigating GWP without reducing rice yields using drought-resistant rice varieties, such as HY3.