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Comment
. 2017 Jan 5;129(1):9-10.
doi: 10.1182/blood-2016-11-749143.

Targeting CD19: the good, the bad, and CD81

Mireya Paulina Velasquez  1 , Stephen Gottschalk  1
Affiliations
Comment

Targeting CD19: the good, the bad, and CD81

Mireya Paulina Velasquez et al. Blood. .

Abstract

In this issue of Blood, Braig et al have identified a novel mechanism of CD19-targeted immune escape.

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Conflict of interest statement

Conflict-of-interest disclosure: The Center for Cell and Gene Therapy at Baylor College of Medicine had a research collaboration with Celgene and Bluebird Bio, and currently has research collaborations with Cell Medica and Tessa Therapeutics. M.P.V. and S.G. have patents and/or patent applications in the fields of T-cell therapy and/or oncolytics.

Figures

None
Mechanisms of CD19-targeted immune escape. The B-cell coreceptor complex consists of CD19, CD21, CD81, and CD225 (for simplicity CD225 is omitted here). It is assembled in the rough endoplasmic reticulum (rER) and transported to the Golgi apparatus where the carbohydrate moieties are processed before being transported to the cell surface. Carbohydrate processing is indicated only for CD19 (light red: unprocessed carbohydrates; dark red: processed carbohydrates). (A) Normal processing and transport of CD19. (B) Splice variants resulting in loss of the extracellular domain of CD19. (C) Mutations resulting in a conformational change of the extracellular domain of CD19. (D) Loss of CD81 expression resulting in intracellular accumulation of CD19 with unprocessed carbohydrates. (E) Lineage switch resulting in transcriptional silencing of CD19 expression.
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