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Review
. 2019 Nov-Dec:151-152:191-221.
doi: 10.1016/j.addr.2019.04.007. Epub 2019 Apr 25.

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

Christina Leichner  1 , Max Jelkmann  1 , Andreas Bernkop-Schnürch  2
Affiliations
Review

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

Christina Leichner et al. Adv Drug Deliv Rev. 2019 Nov-Dec.

Abstract

Thiolated polymers designated "thiomers" are obtained by covalent attachment of thiol functionalities on the polymeric backbone of polymers. In 1998 these polymers were first described as mucoadhesive and in situ gelling compounds forming disulfide bonds with cysteine-rich substructures of mucus glycoproteins and crosslinking through inter- and intrachain disulfide bond formation. In the following, it was shown that thiomers are able to form disulfides with keratins and membrane-associated proteins exhibiting also cysteine-rich substructures. Furthermore, permeation enhancing, enzyme inhibiting and efflux pump inhibiting properties were demonstrated. Because of these capabilities thiomers are promising tools for drug delivery guaranteeing a strongly prolonged residence time as well as sustained release on mucosal membranes. Apart from that, thiomers are used as drugs per se. In particular, for treatment of dry eye syndrome various thiolated polymers are in development and a first product has already reached the market. Within this review an overview about the thiomer-technology and its potential for different applications is provided discussing especially the outcome of studies in non-rodent animal models and that of numerous clinical trials. Moreover, an overview on product developments is given.

Keywords: Drug delivery; Regenerative medicine; Thiol-ene reactions; Thiol/disulfide exchange reactions; Thiolated; Thiolated polymers; Thiomers; Tissue engineering.

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