Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement

doi:10.5664/jcsm.8062

. 2019 Nov 15;15(11):1671-1673.

doi: 10.5664/jcsm.8062.

Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement

Affiliations

¹ Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
² Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
³ Sleep Medicine, Atrium Health, Charlotte, North Carolina.
⁴ Saint Thomas Medical Partners - Sleep Specialists, Nashville, Tennessee.
⁵ Sleep Medicine Center, Washington University School of Medicine, St. Louis, Missouri.
⁶ Division of Pulmonary and Critical Care Medicine, Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota.
⁷ Millennium Physician Group, Fort Myers, Florida.
⁸ University of Pittsburgh, Pittsburgh, Pennsylvania.
⁹ Veteran Affairs Greater Los Angeles Healthcare System, North Hills, California.
¹⁰ David Geffen School of Medicine at the University of California, Los Angeles, California.
¹¹ Department of Pediatrics, Case Western Reserve University, University Hospitals - Cleveland Medical Center, Cleveland, Ohio.
¹² Wayne State University, Detroit, Michigan.
¹³ University of Michigan Sleep Disorders Center, University of Michigan, Ann Arbor, Michigan.

PMID: 31739858
PMCID: PMC6853382
DOI: 10.5664/jcsm.8062

Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement

Ilene M Rosen et al. J Clin Sleep Med. 2019.

. 2019 Nov 15;15(11):1671-1673.

doi: 10.5664/jcsm.8062.

Authors

Affiliations

¹ Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
² Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
³ Sleep Medicine, Atrium Health, Charlotte, North Carolina.
⁴ Saint Thomas Medical Partners - Sleep Specialists, Nashville, Tennessee.
⁵ Sleep Medicine Center, Washington University School of Medicine, St. Louis, Missouri.
⁶ Division of Pulmonary and Critical Care Medicine, Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota.
⁷ Millennium Physician Group, Fort Myers, Florida.
⁸ University of Pittsburgh, Pittsburgh, Pennsylvania.
⁹ Veteran Affairs Greater Los Angeles Healthcare System, North Hills, California.
¹⁰ David Geffen School of Medicine at the University of California, Los Angeles, California.
¹¹ Department of Pediatrics, Case Western Reserve University, University Hospitals - Cleveland Medical Center, Cleveland, Ohio.
¹² Wayne State University, Detroit, Michigan.
¹³ University of Michigan Sleep Disorders Center, University of Michigan, Ann Arbor, Michigan.

PMID: 31739858
PMCID: PMC6853382
DOI: 10.5664/jcsm.8062

Abstract

There is a complex relationship among opioids, sleep and daytime function. Patients and medical providers should be aware that chronic opioid therapy can alter sleep architecture and sleep quality as well as contribute to daytime sleepiness. It is also important for medical providers to be cognizant of other adverse effects of chronic opioid use including the impact on respiratory function during sleep. Opioids are associated with several types of sleep-disordered breathing, including sleep-related hypoventilation, central sleep apnea (CSA), and obstructive sleep apnea (OSA). Appropriate screening, diagnostic testing, and treatment of opioid-associated sleep-disordered breathing can improve patients' health and quality of life. Collaboration among medical providers is encouraged to provide high quality, patient-centered care for people who are treated with chronic opioid therapy.

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Comment in

Thoughts on the 2019 American Academy of Sleep Medicine position statement on chronic opioid therapy and sleep.
Lavigne GJ, Herrero Babiloni A, Mayer P, Daoust R, Martel MO. Lavigne GJ, et al. J Clin Sleep Med. 2020 May 15;16(5):831-833. doi: 10.5664/jcsm.8368. Epub 2020 Feb 13. J Clin Sleep Med. 2020. PMID: 32052741 Free PMC article.

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References

1. Cao M, Javaheri S. Effects of chronic opioid use on sleep and wake. Sleep Med Clin. 2018;13(2):271–281. - PubMed
1. American Academy of Pain Medicine Use of opioids for the treatment of chronic pain. https://painmed.org/uploads/about/position-statements/use-of-opioids-for.... Approved February 2013. Accessed Aug. 29, 2019.
1. Mogri M, Khan MIA, Grant BJB, et al. Central sleep apnea induced by acute ingestion of opioids. Chest. 2008;133(6):1484–1488. - PubMed
1. Webster LR, Choi Y, Desai H, et al. Sleep-disordered breathing and chronic opioid therapy. Pain Med. 2008;9(4):425–432. - PubMed
1. Sharkey KM, Kurth ME, Anderson BJ, et al. Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints. Drug Alcohol Depend. 2010;108(1-2):77–83. - PMC - PubMed

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[1] Cao M, Javaheri S. Effects of chronic opioid use on sleep and wake. Sleep Med Clin. 2018;13(2):271–281. - PubMed

[2] Cao M, Javaheri S. Effects of chronic opioid use on sleep and wake. Sleep Med Clin. 2018;13(2):271–281. - PubMed

[3] American Academy of Pain Medicine Use of opioids for the treatment of chronic pain. https://painmed.org/uploads/about/position-statements/use-of-opioids-for.... Approved February 2013. Accessed Aug. 29, 2019.

[4] American Academy of Pain Medicine Use of opioids for the treatment of chronic pain. https://painmed.org/uploads/about/position-statements/use-of-opioids-for.... Approved February 2013. Accessed Aug. 29, 2019.

[5] Mogri M, Khan MIA, Grant BJB, et al. Central sleep apnea induced by acute ingestion of opioids. Chest. 2008;133(6):1484–1488. - PubMed

[6] Mogri M, Khan MIA, Grant BJB, et al. Central sleep apnea induced by acute ingestion of opioids. Chest. 2008;133(6):1484–1488. - PubMed

[7] Webster LR, Choi Y, Desai H, et al. Sleep-disordered breathing and chronic opioid therapy. Pain Med. 2008;9(4):425–432. - PubMed

[8] Webster LR, Choi Y, Desai H, et al. Sleep-disordered breathing and chronic opioid therapy. Pain Med. 2008;9(4):425–432. - PubMed

[9] Sharkey KM, Kurth ME, Anderson BJ, et al. Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints. Drug Alcohol Depend. 2010;108(1-2):77–83. - PMC - PubMed

[10] Sharkey KM, Kurth ME, Anderson BJ, et al. Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints. Drug Alcohol Depend. 2010;108(1-2):77–83. - PMC - PubMed

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Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement

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Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement

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