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Review
. 2022 Mar;32(3):873-891.
doi: 10.1007/s11695-021-05783-2. Epub 2022 Jan 4.

Vitamin B Complex Deficiency After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy-a Systematic Review and Meta-Analysis

Rita Nunes  1 , Hugo Santos-Sousa  2   3 , Sofia Vieira  1 , Jorge Nogueiro  1   4 , Raquel Bouça-Machado  5 , André Pereira  1   4 , Silvestre Carneiro  1   4 , André Costa-Pinho  1   6 , Eduardo Lima-da-Costa  6 , John Preto  6 , C R I-O Group
Affiliations
Review

Vitamin B Complex Deficiency After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy-a Systematic Review and Meta-Analysis

Rita Nunes et al. Obes Surg. 2022 Mar.

Abstract

Bariatric surgery, although an effective method, still has complications, like nutritional deficiencies. Our aim was to summarize the evidence on the frequency of complex B vitamin deficiencies in studies comparing Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). We included 25 studies for qualitative synthesis and 21 studies for quantitative synthesis. Relevant data was extracted, including proportion of patients with deficiency and mean serum vitamin values in 3 different timeframes. B12 and folate were the most prevalent deficiencies. B12 deficiency was more common after RYGB and folate serum mean levels were higher after RYGB. SG causes less nutrient deficiency and is therefore a better technique from this point of view. More studies are needed on B2, B3, and B6 vitamins to draw better conclusions.

Keywords: Bariatric surgery; Obesity; Roux-en-Y gastric bypass; Sleeve gastrectomy; Vitamin B complex deficiencies.

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