Interleukin 1 is a radioprotector
- PMID: 3512714
Interleukin 1 is a radioprotector
Abstract
Pretreatment with recombinant interleukin 1 (IL 1) protects mice in a dose-dependent manner from lethal effects of ionizing radiation. Two thousand units of IL 1, given i.p. 20 hr before irradiation, protect 88% of C57B1/6 mice from an LD100/17 radiation dose (dose of radiation that kills 100% mice in 17 days), and 1000 U of IL 1 protect 100% of DBA/1 mice from an LD50/30 dose. This finding provides the first evidence that a cytokine, IL 1, which acts as a differentiation- and maturation-inducing agent for a variety of cells, also can serve as a signal that initiates radioprotective events in vivo. Because many of the exogenous immunomodulators that have been shown to be radioprotective also induce endogenous IL 1 production, our observation suggests that IL 1 may mediate their radioprotective effects.
Similar articles
-
Pretreatment with thymus cell-conditioned medium enhances the whole-animal survival of mice exposed to ionizing radiation.Folia Biol (Praha). 1990;36(6):344-50. Folia Biol (Praha). 1990. PMID: 2279588
-
The adjuvanticity of interleukin 1 in vivo.J Immunol. 1983 May;130(5):2191-4. J Immunol. 1983. PMID: 6601146
-
Radiation protection and restoration by the synthetic 163-171 nonapeptide of human interleukin 1 beta.Radiat Res. 1991 Oct;128(1):43-7. Radiat Res. 1991. PMID: 1924727
-
Interleukin-1 as an adjuvant for tumor vaccines increases survival in mice.Biotherapy. 1989;1(4):355-9. doi: 10.1007/BF02171011. Biotherapy. 1989. PMID: 2701649 Review. No abstract available.
-
An overview on interleukin-1 as a therapeutic agent.Biotherapy. 1989;1(4):245-54. doi: 10.1007/BF02171000. Biotherapy. 1989. PMID: 2701640 Review. No abstract available.
Cited by
-
Occupational levels of radiation exposure induce surface expression of interleukin-2 receptors in stimulated human peripheral blood lymphocytes.Radiat Environ Biophys. 1996 May;35(2):89-93. doi: 10.1007/BF02434030. Radiat Environ Biophys. 1996. PMID: 8792455
-
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives.J Inflamm Res. 2015 Jan 16;8:15-27. doi: 10.2147/JIR.S51250. eCollection 2015. J Inflamm Res. 2015. PMID: 25653548 Free PMC article. Review.
-
Dissociation of cell-associated interleukin-1 (IL-1) and IL-1 release induced by lipopolysaccharide and lipid A.Infect Immun. 1989 Mar;57(3):791-7. doi: 10.1128/iai.57.3.791-797.1989. Infect Immun. 1989. PMID: 2537258 Free PMC article.
-
Effect of human macrophage colony-stimulating factor on granulopoiesis and survival in bone-marrow-transplanted mice.Jpn J Cancer Res. 1990 Apr;81(4):355-62. doi: 10.1111/j.1349-7006.1990.tb02575.x. Jpn J Cancer Res. 1990. PMID: 2114389 Free PMC article.
-
Clinical significance of the haemopoietic growth factors.Br J Cancer. 1989 Jan;59(1):2-5. doi: 10.1038/bjc.1989.2. Br J Cancer. 1989. PMID: 2667609 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources