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. 1986 Jan;5(1):33-8.
doi: 10.1007/BF02030965.

Cellular localization of the Ro/SS-A antigen

E Lopez-Robles, R Herrera-Esparza, E Avalos-Diaz

Cellular localization of the Ro/SS-A antigen

E Lopez-Robles et al. Clin Rheumatol. 1986 Jan.

Abstract

The cellular localization of the Ro/SS-A antigen was defined using indirect immunofluorescence and eight monospecific anti- Ro/SS-A antisera which were identified by immunoblotting. Several mammalian tissues were used as substrates. The Ro/SS-A antigen was located mainly in the nucleus of dog liver and Hep-2-cells, and anti-Ro sera had produced a speckled staining pattern. Cytoplasmic fluorescence appeared only in one serum. IgG was the predominant immunoglobulin with anti-Ro/SS-A activity; five sera had complement fixing activity. The sera absorption studies with partially purified Ro/SS-A antigen and the negativation of the ANA tests had confirmed the specificity of our findings.

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