Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov 3:9:1049016.
doi: 10.3389/fmolb.2022.1049016. eCollection 2022.

Applications of liquid chromatography-mass spectrometry based metabolomics in predictive and personalized medicine

Juntuo Zhou  1 , Lijun Zhong  2
Affiliations
Review

Applications of liquid chromatography-mass spectrometry based metabolomics in predictive and personalized medicine

Juntuo Zhou et al. Front Mol Biosci. .

Abstract

Metabolomics is a fast-developing technique used in biomedical researches focusing on pathological mechanism illustration or novel biomarker development for diseases. The ability of simultaneously quantifying thousands of metabolites in samples makes metabolomics a promising technique in predictive or personalized medicine-oriented researches and applications. Liquid chromatography-mass spectrometry is the most widely employed analytical strategy for metabolomics. In this current mini-review, we provide a brief update on the recent developments and novel applications of LC-MS based metabolomics in the predictive and personalized medicine sector, such as early diagnosis, molecular phenotyping or prognostic evaluation. COVID-19 related metabolomic studies are also summarized. We also discuss the prospects of metabolomics in precision medicine-oriented researches, as well as critical issues that need to be addressed when employing metabolomic strategy in clinical applications.

Keywords: COVID; liquid chromatography; mass spectrometry; metabolomics; personalized medicine; predictive medicine.

PubMed Disclaimer

Conflict of interest statement

Author JZ was employed by Beijing Boyuan Precision Medicine Co., Ltd. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the typical steps of precision medicine-oriented metabolomic researches.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bajaj J. S., Garcia-Tsao G., Reddy K. R., O'Leary J. G., Vargas H. E., Lai J. C., et al. (2021). Admission urinary and serum metabolites predict renal outcomes in hospitalized patients with cirrhosis. Hepatology 74 (5), 2699–2713. 10.1002/hep.31907 - DOI - PMC - PubMed
    1. Beitler J. R., Thompson B. T., Baron R. M., Bastarache J. A., Denlinger L. C., Esserman L., et al. (2022). Advancing precision medicine for acute respiratory distress syndrome. Lancet. Respir. Med. 10 (1), 107–120. 10.1016/s2213-2600(21)00157-0 - DOI - PMC - PubMed
    1. Bieber T. (2022). Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat. Rev. Drug Discov. 21 (1), 21–40. 10.1038/s41573-021-00266-6 - DOI - PMC - PubMed
    1. Chen F., Dai X., Zhou C. C., Li K. X., Zhang Y. J., Lou X. Y., et al. (2022). Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma. Gut 71 (7), 1315–1325. 10.1136/gutjnl-2020-323476 - DOI - PMC - PubMed
    1. Crosby D., Bhatia S., Brindle K. M., Coussens L. M., Dive C., Emberton M., et al. (2022). Early detection of cancer. Science 375 (6586), eaay9040. 10.1126/science.aay9040 - DOI - PubMed

LinkOut - more resources