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Review
. 2024 May;30(4):1887-1896.
doi: 10.1111/odi.14748. Epub 2023 Sep 28.

The role of Semaphorin 3A in oral diseases

Xinyue Zhang  1 , Zhenqi Yang  1 , Demao Zhang  2 , Mingru Bai  1
Affiliations
Review

The role of Semaphorin 3A in oral diseases

Xinyue Zhang et al. Oral Dis. 2024 May.

Abstract

Semaphorin 3A (SEMA3A), also referred to as H-Sema III, is a molecule with significant biological importance in regulating physiological and pathological processes. However, its role in oral diseases, particularly its association with inflammatory immunity and alveolar bone remodeling defects, remains poorly understood. This comprehensive review article aims to elucidate the recent advances in understanding SEMA3A in the oral system, encompassing nerve formation, periodontitis, pulpitis, apical periodontitis, and oral squamous cell carcinoma. Notably, we explore its novel function in inflammatory immunomodulation and alveolar bone formation during oral infectious diseases. By doing so, this review enhances our comprehension of SEMA3A's role in oral biology and opens up possibilities for modulatory approaches and potential treatments in oral diseases.

Keywords: Semaphorin 3A; apical periodontitis; oral diseases; periodontitis.

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