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. 1979 Mar 16;203(4385):1115-7.
doi: 10.1126/science.424739.

DNA repair and longevity assurance in Paramecium tetraurelia

J Smith-Sonneborn

DNA repair and longevity assurance in Paramecium tetraurelia

J Smith-Sonneborn. Science. .

Abstract

At given doses and clonal ages, ultraviolet irradiation-induced DNA damage reduced clonal life-span, but when followed by photoreactivation, extension of clonal life-span was observed. If photoreactivation preceded the ultraviolet treatment, no significant beneficial effect was detected. Because studies of others have shown that photoreactivation repair monomerizes the ultraviolet-induced cyclobutane dimers in DNA, but does not affect the other photoproducts, these results indicate that DNA damage can influence the duration of clonal life-span unless that damage is repaired. Repeated treatment with ultraviolet and photoreactivation resulted in significant mean and maximal clonal life-span extension when compared with untreated controls, and it is assumed that the rejuvenation effect was due to the correction or prevention of some age damage.

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