doi: 10.1016/0304-3835(83)90165-9.
Tumorigenicity of citrinin in male F344 rats
- PMID: 6831385
- DOI: 10.1016/0304-3835(83)90165-9
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Tumorigenicity of citrinin in male F344 rats
Cancer Lett.
1983 Jan.
Abstract
This study reports on the tumorigenicity of citrinin, a nephrotoxic mycotoxin. Male F344 rats were fed 0.1% citrinin in the diet for up to 80 weeks. The first renal tumor was seen grossly in a rat receiving citrinin which was killed at week 52. Histopathology of the kidneys showed renal adenomas in 35 of 48 (72.9%) rats that survived after 40 weeks. No renal tumors were seen in the control rats.
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