doi: 10.1016/0014-5793(95)01094-u.
Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase
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- PMID: 7589562
- DOI: 10.1016/0014-5793(95)01094-u
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Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase
FEBS Lett.
.
Free article
Abstract
The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFN alpha. In this report we show a ligand-independent interaction between Tyk-2 and Jak-1 kinases. We also demonstrate that the Tyk-2 kinase forms a homodimer that has the ability to undergo intermolecular tyrosine phosphorylation. The formation of the Tyk-2 homodimer is independent of both tyrosine phosphorylation and the presence of the tyrosine kinase domain.
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