Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Apr 30;93(9):3892-7.
doi: 10.1073/pnas.93.9.3892.

Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture

R Lahav  1 , C Ziller, E Dupin, N M Le Douarin
Affiliations

Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture

R Lahav et al. Proc Natl Acad Sci U S A. .

Abstract

Mutations in the endothelin 3 (EDN3) gene severely affect the development of neural crest-derived melanocytes. In this paper, we report the action of EDN3 on neural crest cells in vitro. The presence of EDN3 leads to a large increase in the number of cells, the majority of which eventually differentiate into melanocytes that aggregate to form a reproducible pigmentation pattern. Quantitative analysis of the effect of different culture conditions revealed that EDN3 initially promotes neural crest cell proliferation. This phase of expansion, which can be prolonged for a few weeks if the cells are replaced regularly, is followed by both a decrease in cell proliferation and the onset of melanocytic differentiation. Therefore, EDN3 is a potent mitogen for early neural crest cell precursors that can give rise to melanocytes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Dev Biol. 1977 APR;56(2):255-62 - PubMed
    1. Dev Biol. 1964 Apr;9:269-86 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6358-62 - PubMed
    1. Development. 1991 May;112(1):301-5 - PubMed
    1. Dev Biol. 1992 Jun;151(2):368-76 - PubMed

Publication types

LinkOut - more resources