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. 1996 Jun 25;223(3):701-5.
doi: 10.1006/bbrc.1996.0959.

Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif

D Grbavec  1 , S Stifani
Affiliations

Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif

D Grbavec et al. Biochem Biophys Res Commun. .

Abstract

Groucho is a protein implicated in Notch signaling and involved in segmentation and neural development in Drosophila. Groucho forms transcription complexes with the basic helix-loop-helix proteins encoded by the hairy/Enhancer of split ("hairy-like") gene family. These interactions are mediated by the carboxyl-terminal WRPW motif of Hairy-like proteins. We are interested in determining whether Groucho and its mammalian homologues, the TLE proteins, perform conserved functions. We show that TLE1 interacts with HES-1, a murine homologue of Drosophila Hairy-like proteins, both in the yeast two-hybrid assay and in an interaction assay based on glutathione S-transferase fusion proteins. These results show that Groucho/TLE proteins and Hairy-like/HES proteins are involved in similar interactions in Drosophila and mammals and further suggest that these proteins perform conserved cellular functions.

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