Fenilpiperazin

Fenilpiperazin
	1-phenylpiperazine
Identifikacija
CAS registarski broj	92-54-6
PubChem	7096
ChemSpider	6829
ChEMBL	CHEMBL9434
Jmol-3D slike	Slika 1
SMILES
	c1cc(ccc1)N2CCNCC2
InChI
	InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 ; Kod: YZTJYBJCZXZGCT-UHFFFAOYSA-N InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2; Kod: YZTJYBJCZXZGCT-UHFFFAOYSA-N
Svojstva
Molekulska formula	C10H14N2
Molarna masa	162.23 g/mol
Agregatno stanje	čista bezbojna do žute tečnosti
Gustina	1.028g/cm3
Tačka topljenja	18.8 °C
Tačka ključanja	287.2 °C @ 760mmHg
Rastvorljivost u vodi	nerastvoran
Opasnost
Tačka paljenja	138.3 °C
	; ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

1-Fenilpiperazin je jednostavno hemijsko jedinjenje koje sadrži fenilna grupa:fenilnu grupu vezanu za piperazinski prsten. Sufiks '-piprazol' se ponekad koristi u imenima lekova da se naznači da pripadaju ovoj klasi.^[5]^[6]

Brojni fenilpiperazinski derivati su lekovi. Neki od njih su:

Lekovi
- Antrafenin - Antiinflamatorni lek
- Aripiprazol - Antipsihotik
- Ciprofloksacin - Antibiotic
- Dapiprazol - Alfa blokator
- Dropropizin - Antitusiv
- Etoperidon - Antidepresiv
- Itrakonazol - Antifungal
- Ketokonazol - Antifungal
- Levodropropizin - Antitusiv
- Mepiprazol - Anksiolitik
- Naftopidil - Antihipertenziv
- Nefazodon - Antidepresiv
- Niaprazin - Hipnotik
- Oksipertin - Antipsihotik
- Posakonazol - Antifungal
- Trazodon - Antidepresiv
- Urapidil - Antihipertenziv
- Vesnarinon - Kardiotonik
Istraživačke hemikalije
- Akaprazin - Anksiolytik
- Batoprazin - Serenik
- Bifeprunoks - Antipsihotik
- BRL-15,572 - Serotonergik
- CSP-2503 - Anksiolitik
- DMPP - Nikotinik
- EGIS-12,233 - Serotonergik
- Elopiprazol - Antipsihotik
- Eltoprazin - Serenik
- Enpiprazol - Anksiolitik
- Ensakulin - Nootropik
- Flibanserin - Afrodizijak
- Fluprazin - Serenik
- Flesinoksan - Antidepresiv
- Lorpiprazol - Anksiolitik
- Naftilpiperazin - Serotonergik
- Pardoprunoks - Antiparkinsonijan
- PRX-00023 - Antidepresiv
- S-14,506 - Serotonergik
- S-14,671 - Serotonergik
- S-15,535 - Serotonergik
- SB-258,585 - Serotonergik
- SB-271,046 - Serotonergik
- SB-357,134 - Serotonergik
- SB-399,885 - Serotonergik
- Sonepiprazol - Dopaminergik
- Tolpiprazol - Anksiolitik
- Vilazodon - Antidepresiv
- WAY-100,135 - Serotonergik
- WAY-100,635 - Serotonergik
Lekovi u razvoju
- DCPP - Serotonergik
- mCPP - Serotonergik
- MeOPP - Serotonergik
- pCPP - Serotonergic
- pFPP - Serotonergic
- TFMPP - Serotonergik

Povezano

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ World Health Organization (WHO) (2006). „The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances” (PDF). The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Pristupljeno April 2010.
↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.

Literatura

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[The_use_of_stems_in_the_selection_of_International_Nonproprietary_Names_(INN)_for_pharmaceutical_substances-5] World Health Organization (WHO) (2006). „The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances” (PDF). The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Pristupljeno April 2010.

[6] Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.

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