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Bioinformatics

Bioinformatics is an interdisciplinary field that intersects with biology, computer science, mathematics and statistics. It concerns itself with the development and use of methods and software tools for collecting and analyzing biological data.

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dash
nextflow
twbattaglia
twbattaglia commented Jan 7, 2020

New feature

Ability to specify the Compute Engine disk type (pd-standard or local-SSD) found in the new Cloud Life Sciences API (https://cloud.google.com/life-sciences/docs/reference/rpc/google.cloud.lifesciences.v2beta#disk).

Usage scenario

Job's that require a high input/output operations per second and lower latency (https://cloud.google.com/compute/docs/disks/local-ssd).

S

mdkeehan
mdkeehan commented Apr 3, 2018

I am planning a large alignment run on a non human species using a non alt aware reference.
I would like to determine which combination of BWA MEM "-M" and "-Y" options I should be using.
As far as I can tell "-M" used to be needed for the Picard compatibility as sometimes mentioned in the man page.

GATK 4 now recommends not to use "-M" for the human alt aware reference.
But they are now rec

samuell
samuell commented May 5, 2018

Add a new method:

proc.SetPathAuditHashed(portName string, prefix string, suffix string)

... which will create a SHA1(?) hash the port name plus all the command, parameters, and upstream commands and parameters used to create the specific file.

Usage example:

proc.SetPathAuditHashed("csvfile", "dat/", ".csv")

Internally, it should use a function, that can als

tshtatland
tshtatland commented Dec 22, 2016

When seqtk sample requests more reads (integer argument) than there are reads in the input, the input is returned and no warnings are written to STDERR. Exit status is 0 (success).

This behavior may not be obvious to all users and I could not find it quickly in user docs. Please add this to the docs if this is in fact the intended behavior. Thank you!

scanpy
hail
hammer
hammer commented Jan 30, 2020

I tried to run Hail with Spark 2.4.4 built for Scala 2.12, and it did not work. It does work with Spark 2.4.4 built for Scala 2.11.

Here's the error I got with Scala 2.12:

Py4JJavaError: An error occurred while calling z:is.hail.HailContext.apply.
: java.lang.NoSuchMethodError: scala/Predef$.refArrayOps([Ljava/lang/Object;)Lscala/collection/mutable/ArrayOps; (loaded from file:/home/hammer

ewels
ewels commented Nov 29, 2019

By far the worst part of the docs is for Custom Content. This could do with a rewrite, with much more explicit instructions of what is possible and where to find more information about configuration and organisation.

Embedding lots of examples from the TestData repo will help people a lot I think.

scispacy
ChantalvanSon
ChantalvanSon commented Mar 10, 2020

First of all, thanks for creating scispacy, I think it's an amazing tool and very useful!!

I was running into an issue when saving the output of scispacy. I tried to pickle a Doc object, as explained on the website of spaCy, as follows:

import spacy
import pickle

nlp = spacy.load("en_core_sci_sm")

# add the Abbreviation Detector
abbrev
iamtmrobinson
iamtmrobinson commented May 30, 2018

The installation section currently says to use npm install --save circos with no further instruction.

Doing just this and then using Browserify to require circos results in the following error:
Error: Cannot find module '!!../../node_modules/css-loader/index.js!./tooltip.css' from '/.../node_modules/circos/dist'

Is there an assumption that Webpack is being used by those who try to impo

JFsanchezherrero
JFsanchezherrero commented Mar 20, 2019

Dear @kblin,

I would like to use ncbi-gneome-download as a python module within my pipeline and I have been having problems to decipher the arguments to pass to the download call. I guess the readme and documentation is not up to date or I am missing something.

For example, I tried on the command line and it worked fine for me the following code:

ncbi-genome-download -s genbank -F fast
Wikipedia
Wikipedia

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genomics sequencing
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