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pystatgen / sgkit

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Consider adding mean imputation function

eric-czech
eric-czech commented Jun 15, 2021

For association testing and PCA (at least), it may be useful to have a function that imputes dosages/allele counts. With floating point values (i.e. from bgen), this can be very simple as a user, e.g. ds.call_genotype_probability.fillna(ds.call_genotype_probability.mean(dim="samples")). With alternate allele counts having a sentinel integer, it is a little more complicated. The best way t

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good first issue help wanted core operations

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