If python is built with a non standard location interpreter, it is possible the location of this interpreter has a string length which will cause issues on systems with shebang string length limitations. An example is in Linux systems where the maximum (!#) shebang size is defined in include/uapi/linux/binfmts.h and is 128 characters

This issue happens if python-config.py is invoked directly. The script will not even be executed by the operating system.