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tweek tweek [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35026, updated on 23-Apr-2025

Summary

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Official Symbol
tweekprovided by FlyBase
Official Full Name
tweekprovided by FlyBase
Primary source
FLYBASE:FBgn0261671
Locus tag
Dmel_CG42555
See related
AllianceGenome:FB:FBgn0261671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15133; CG15134; CG42555; CG42706; CG4841; Dmel\CG42555; Tweek
Old locus tag
Dmel_CG15133; Dmel_CG15134; Dmel_CG4841
Summary
Involved in regulation of synaptic vesicle endocytosis and synaptic vesicle endocytosis. Is active in neuromuscular junction. Is expressed in adult head; embryonic hindgut; embryonic/larval midgut primordium; ganglia; and spermatozoon. Human ortholog(s) of this gene implicated in Alkuraya-Kucinskas syndrome. Orthologous to human BLTP1 (bridge-like lipid transfer protein family member 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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Genomic context

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See tweek in Genome Data Viewer
Location:
36B3-36B4; 2-53 cM
Exon count:
24
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16888490..16917052)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16888490..16917052)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44392 Neighboring gene uncharacterized protein Neighboring gene orsai Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aminopeptidase P Neighboring gene long non-coding RNA:CR43053 Neighboring gene long non-coding RNA:CR44393

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterizing dopaminergic neuron vulnerability using genome-wide analysis. Davis J, et al. Genetics, 2021 Aug 9. PMID 34038543, Free PMC Article
  2. Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin. Blundon MA, et al. Development, 2016 Jul 15. PMID 27287809, Free PMC Article
  3. WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Khuong TM, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20844206, Free PMC Article
  4. Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Verstreken P, et al. Neuron, 2009 Jul 30. PMID 19640479, Free PMC Article
  5. Toxicological Study and Genetic Basis of BTEX Susceptibility in Drosophila melanogaster. Adebambo TH, et al. Front Genet, 2020. PMID 33193742, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tweek
Names
CG42555-PF
CG42555-PG
CG42555-PH
CG42555-PI
CG42555-PJ
CG42555-PK
tweek-PF
tweek-PG
tweek-PH
tweek-PI
tweek-PJ
tweek-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16888490..16917052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299073.1 → NP_001286002.1  tweek, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286002.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JA38
    Conserved Domains (1) summary
    pfam10479
    Location:4415 → 5113
    FSA_C; Fragile site-associated protein C-terminus

  2. NM_001299074.1 → NP_001286003.1  tweek, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286003.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAP2
    Conserved Domains (1) summary
    pfam10479
    Location:4381 → 5073
    FSA_C; Fragile site-associated protein C-terminus

  3. NM_001201897.2 → NP_001188826.2  tweek, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188826.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRK7
    Conserved Domains (1) summary
    pfam10479
    Location:4387 → 5079
    FSA_C; Fragile site-associated protein C-terminus

  4. NM_001201895.2 → NP_001188824.2  tweek, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188824.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRV1
    Conserved Domains (1) summary
    pfam10479
    Location:4367 → 5059
    FSA_C; Fragile site-associated protein C-terminus

  5. NM_001201896.2 → NP_001188825.2  tweek, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188825.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRP6
    Conserved Domains (1) summary
    pfam10479
    Location:4366 → 5058
    FSA_C; Fragile site-associated protein C-terminus

  6. NM_001201898.2 → NP_001188827.2  tweek, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188827.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSI8
    Conserved Domains (1) summary
    pfam10479
    Location:4346 → 5038
    FSA_C; Fragile site-associated protein C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MRK7 M9MRK7
M9MRP6 M9MRP6
M9MRV1 M9MRV1
M9MSI8 M9MSI8
Q8T620 Q8T620
X2JA38 X2JA38
X2JAP2 X2JAP2

Gene LinkOut

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